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Preliminary experimental study on a novel device using biomaterial for shunting fibrotic bleb following Ahmed glaucoma valve surgery in dogs.
Sci Rep
January 2025
Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
This study aimed to design and evaluate a novel trans-bleb device (TBD) for draining aqueous humor trapped within fibrotic blebs following Ahmed glaucoma valve (AGV) implantation in dogs. Two clinically normal, purpose-bred Beagles underwent AGV implantation surgery in one eye. When a bleb was formed with increased intraocular pressure (IOP), the TBD was inserted through a fenestration created in the bleb.
View Article and Find Full Text PDFRepair effects of thermosensitive hydrogels combined with iPSC-derived corneal endothelial cells on rabbit corneal endothelial dysfunction.
Acta Biomater
January 2025
Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address:
Article Synopsis
- The study addresses the challenges of corneal endothelial cell transplantation, which is limited by a shortage of donors and the inability of human corneal endothelial cells to proliferate effectively.
- Researchers developed a new transplantation method using thermosensitive hydrogels combined with human corneal endothelial cells derived from induced pluripotent stem cells (iPSCs).
- Results showed that the hydrogels had excellent transparency and biocompatibility, and the combination method improved corneal transparency in a rabbit model, suggesting potential for treating corneal endothelial dysfunction.
Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression.
Sci Rep
October 2024
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China.
Article Synopsis
- - Meibomian gland dysfunction (MGD) is a chronic eye condition characterized by meibomian gland blockages and lipid issues, and a rat model was developed to study the mechanisms behind these obstructions.
- - The study involved assessing tear production, tear film stability, and structural changes in the meibomian glands over 4, 8, and 16 weeks using various staining techniques and RNA sequencing.
- - Findings indicated that prolonged meibomian gland obstruction leads to significant histological changes, increased corneal damage, and altered gene expression related to lipid metabolism and inflammatory pathways, suggesting that such obstructions are a key cause of MGD.
Living histopathology - interrogation of ocular tissues by light: a celebration of the slit-lamp and a repertoire of clinical techniques.
Eye (Lond)
October 2024
Visiting Fellow, Cambridge University Department of Engineering; Hon Senior Visiting Fellow, Cambridge University Department of Medicine; Retired Consultant Medical Ophthalmologist, Addenbrooke's Hospital, Cambridge, UK.
The evolution of the slit-lamp microscope has enabled ophthalmologists to examine the transparent tissues of the eye with histological detail. This paper considers the history and optics of the slit-lamp. Optical sectioning and retro-illumination are discussed; particularly, effective placement of the reflected light beam.
View Article and Find Full Text PDFIL-37 Inhibits Inflammation of Lacrimal Gland in Dry Eye Mice via the IL-37-PTEN-NFκB Signaling Pathway.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China.
Purpose: This study aims to investigate the role of Interleukin-37 (IL-37) in mouse models of dry eye.
Methods: Two murine models of dry eye were employed in this investigation. The evaluation of the anti-inflammatory impact of IL-37 (200 μl, 10 μg/ml) on dry eye mice involved intraperitoneal injections administered once daily for 7 days.
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