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Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity.
Immun Ageing
December 2024
Department of Biomedical Sciences, Institute of Health, Jimma University, Jimma, 378, Oromia, Ethiopia.
Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes greatly to rates of chronic inflammation in later life. Such micro nutrients are crucial for modulating effective immune responses and their deficiencies have been associated with dysfunctional immunity in the elderly. In this review, we specifically focused on the contribution of major micro nutrients (Vitamins A, D and E, Vitamin C; Zinc and Selenium) as immunomodulators in ageing population especially related to inflame-ageing process including autoimmunity.
View Article and Find Full Text PDFConventional and Nonconventional Therapies for COVID-19 Management in Trinidad.
Scientifica (Cairo)
November 2024
Department of Basic Veterinary Sciences, School of Veterinary Medicine, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago.
This cross-sectional study investigated nonconventional therapies for COVID-19 in Trinidad, emphasizing the need for documentation supporting future pharmaceutical research. The survey, conducted from June 20 to July 19, 2022, garnered responses from 57 participants aged 18 and above, with 82.46% vaccinated.
View Article and Find Full Text PDFDevelopment and biopharmaceutical evaluation of aqueous micelle based corticosteroid formulations for topical treatment of oral lichen planus.
Int J Pharm
December 2024
School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, 1 Rue Michel Servet, Geneva 1211, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva 1211, Switzerland. Electronic address:
The dearth of approved products to treat oral lichen planus (OLP) compels off-label use of dermatological corticosteroid formulations not optimized for indications in the oral cavity. The aims of this study were to develop aqueous micelle based formulations of triamcinolone acetonide (TA) and fluocinonide (FLU), using D-tocopheryl polyethylene glycol succinate, and to investigate corticosteroid delivery to the epithelium-lamina propria junction region - the anatomical target for OLP treatment - in comparison to that from marketed products. Total mucosal deposition of TA after application of Kenacort® A Orabase® (0.
View Article and Find Full Text PDFNutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections.
J Transl Med
September 2024
, Auckland, New Zealand.
Scope: The underlying medical conditions and gut dysbiosis is known to influence COVID-19 severity in high-risk patients. The current review proposed the optimal usage of nutraceuticals & pharmacological interventions can help regulate the protective immune response and balance the regulatory functionality of gut microbiota. Many studies have revealed that the probiotic interventions viz.
View Article and Find Full Text PDFEfficacy and safety of neridronate in paediatric type I complex regional pain syndrome: a multicentre experience.
Clin Exp Rheumatol
September 2024
Paediatric Division, Academic Hospital of Udine, Udine, Italy.
Objectives: Evidence regarding the efficacy of neridronate in the treatment of complex regional pain syndrome type I (CRPS I) is increasing, however, very little data are available in paediatric age. Our aim was to analyse the safety and the efficacy of neridronate in a case series of children with CRPS I, according to the Budapest criteria, who did not respond to previous pharmacological and physical therapy.
Methods: We collected data of children affected by CRPS I from three paediatric rheumatology centres who received neridronate.
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