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Effects of Betaine and Polydextrose on Intestinal Microbiota and Liver Ergothioneine in a High-Fat Diet-Fed Mouse Model and a Human Colonic Simulation Model.
Nutrients
December 2024
IFF, Health & Biosciences, Sokeritehtaantie 20, 02460 Kantvik, Finland.
Background/objectives: Ergothioneine (EGT) is an effective antioxidant that animals cannot produce and has an important anti-inflammatory role in cell protection, which can help lower the risk of various diseases. In this study, we investigated the potential role of gut microbiota in the production of EGT, which was found to increase in the mouse liver after dietary supplementation with betaine (BET) or polydextrose (PDX).
Methods: The effects of BET and PDX on the gut microbiota and tissue EGT content were investigated using a diet-induced obese mouse model and simulated fermentation in the human colon.
Effect of rPET Content and Preform Heating/Cooling Conditions in the Stretch Blow Molding Process on Microcavitation and Solid-State Post-Condensation of vPET-rPET Blend: Part II-Statistical Analysis and Interpretation of Tests.
Materials (Basel)
December 2024
Faculty of Physics and Astronomy, University of Wroclaw, 9 Maxa Born Square, 50-204 Wroclaw, Poland.
This research explores how varying proportions of virgin polyethylene terephthalate (vPET) and recycled polyethylene terephthalate (rPET) in vPET-rPET blends, combined with preform thermal conditions during the stretch blow molding (SBM) process, influence PET bottles' microscopic characteristics. Key metrics such as viscosity, density, crystallinity, amorphous phase relaxation, and microcavitation were assessed using response surface methodology (RSM). Statistical analysis, including Analysis of variance (ANOVA) and its power, supported the interpretation of results.
View Article and Find Full Text PDFDeep mantle earthquakes linked to CO degassing at the mid-Atlantic ridge.
Nat Commun
January 2025
Cnr-Istituto di Geologia Ambientale e Geoingegneria, Roma, Italy.
Volatiles (CO, HO) play a fundamental role in mantle melting beneath ocean spreading centers, but what role they play during the melt migration remains unknown. Using seismological data recorded by ocean-bottom seismometers, here we report the presence of deep earthquakes at 10-20 km depth in the mantle along the Mid-Atlantic Ridge axis, much below the brittle-ductile boundary. Syntheses of regional basaltic rock samples and their geochemical analyses indicate the presence of an abnormally high quantity of CO (~0.
View Article and Find Full Text PDFDysregulation of Airway and Systemic Interferon Responses Promote Asthma Exacerbations in Urban Children.
J Allergy Clin Immunol
January 2025
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Background: Determining why some upper respiratory illnesses provoke asthma exacerbations remains an unmet need.
Objective: To identify transcriptome-wide gene expression changes associated with colds that progress to exacerbation.
Methods: 208 urban children (6-17 years) with exacerbation-prone asthma were prospectively monitored for up to two cold illnesses.
Probing Single-Cell Adhesion Kinetics and Nanomechanical Force with Surface Plasmon Resonance Imaging.
ACS Nano
January 2025
Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
Single cell adhesion plays a significant role in numerous physiological and pathological processes. Real-time imaging and quantification of single cell adhesion kinetics and corresponding cell-substrate mechanical interaction forces are crucial for elucidating the cellular mechanisms involved in tissue formation, immune responses, and cancer metastasis. Here, we present the development of a plasmonic-based nanomechanical sensing and imaging system (PNMSi) for the real-time measurement of single cell adhesion kinetics and associated nanomechanical forces with plasmonic tracking and monitoring of cell-substrate interactions and the accompanying nanoscale fluctuations.
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