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Targeted Ganglionated Plexi Ablation With Nanoformulated Calcium Suppresses Postoperative AF Via Vagosympatholytic and Anti-Inflammatory Effects.
JACC Clin Electrophysiol
November 2024
Electrophysiology Section, Division of Cardiology, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, USA; Pauley Heart Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. Electronic address:
Background: The mechanisms underlying postoperative atrial fibrillation (POAF) remain unclear.
Objectives: The aim of this study was to test the hypothesis that targeted chemical ganglionated plexi (GP) modulation of all major left atrial-pulmonary vein GP using novel nanoformulated calcium chloride (nCaCl) can reverse postoperative neuroelectrical remodeling by suppressing vagosympathetic nerve activity and the localized inflammatory process, both critical substrates of POAF.
Methods: In a novel canine model of POAF with serial thoracopericardiotomies, sympathetic nerve activity (SNA), vagal nerve activity (VNA) and GP nerve activity (GPNA) were recorded; spontaneous and in vivo AF vulnerability were assessed; and atrial and circulating inflammatory markers and norepinephrine (NE) were measured to determine the neuroelectrical remodeling that promotes POAF and its subsequent modulation with nCaCl GP treatment (n = 6) vs saline sham controls (n = 6).
THE STUDY OUTCOMES OF THE NEGATIVE IMPACT OF HEXACHLOROCYCLOHEXANE ON VEGETOVASCULAR REGULATION OF NEWBORNS' CARDIAC RHYTHM.
Georgian Med News
September 2024
2South Kazakhstan Medical Academy, Kazakhstan.
Introduction: One of the most adverse chemical factors of the outdoor environment is pesticides entering the organism of newborns via mother's breast milk, and also receive a pesticide load through a polluted environment. The heavy demonstration of pesticides impact on the brain is violation of autonomic regulation mechanisms of newborns' cardiac rhythm. The purpose of the study is early detection of violation of autonomic regulation mechanisms of cardiac function of children with perinatal hypoxia in the region of hexachlorocyclohexane use in cotton planting.
View Article and Find Full Text PDFComparison of high-intensity interval training and moderate-intensity continuous training on cardiopulmonary function, cardiac autonomic function and vascular function in adolescent boys with obesity: A randomized controlled trial.
Eur J Sport Sci
December 2024
College of Physical Education, Harbin Sport University, Harbin, Heilongjiang, China.
Article Synopsis
- Adolescent obesity negatively impacts heart and lung function, and this study investigates two exercise methods, moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), to see which is more beneficial.
- 44 obese adolescent boys participated, dividing into HIIT and MICT groups for an 8-week training program, measuring outcomes such as VO (peak oxygen consumption), vascular elasticity, and heart rate variability.
- Results showed both exercise types improved VO equally, but HIIT produced significantly better outcomes for endothelial function and vago-sympathetic balance compared to MICT.
[Effects of the beta-stimulating training in recovery of adaptive reserves in athletes of different sports].
Vopr Kurortol Fizioter Lech Fiz Kult
January 2024
Petrovsky National Research Centre of Surgery, Moscow, Russia.
Unlabelled: Application of the beta rhythm neurofeedback is mainly dealt with when considering issues related to improving attention for clinical or preventive purposes. Cognitive and autonomic interactions formed with the help of biofeedback training, changing the function of autonomic and visceral systems, qualitatively improve the efficiency of any activity, including athletic activity, the nature of which is predetermined by the type of sports.
Objective: To identify effects of the beta-stimulating training in recovery of adaptive reserves in athletes of different sports.
Aim To study the clinical value of markers for myocardial electrical instability in combination with echocardiographic parameters for predicting the risk of cardiovascular complications (CVC) in the postinfarction period.Material and methods This study included 118 patients with ST segment elevation myocardial infarction (STEMI) and hemodynamically significant stenosis of one coronary artery. A percutaneous coronary intervention (PCI) with stenting of the infarct-related artery was performed for all patients.
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