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Chemical Composition and Anti-sickling Activity of the Essential Oil From the Leaves of Lantana Montevidensis (Spreng.) Briq (Verbenaceae) Growing Wild in the Western Region of Democratic Republic of Congo.
Chem Biodivers
January 2025
Department of Chemistry, Faculty of Science, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Lantana montevidensis (Spreng.) Briq. is a shrub native to South American countries.
View Article and Find Full Text PDFUnveiling the therapeutic and nutritious potential of in line with its phytochemistry.
Heliyon
September 2024
Department of Agricultural Sciences, University of Naples Federico II, 80055, Portici, Naples, Italy.
Article Synopsis
- - The cowpea is a significant legume widely cultivated in Africa and Asia, recognized for its traditional roles in disease management, animal feed, and human consumption.
- - The review highlights various compounds found in cowpea, such as flavonoids and alkaloids, which have demonstrated a range of pharmacological effects, including antibacterial and antioxidant properties.
- - Overall, the study urges further research on cowpea's health benefits and nutritional value to better understand its potential clinical applications.
A Review of Gene Therapies for Hemoglobinopathies.
Hemoglobin
May 2024
Dana-Farber Cancer Institute - Department of Medical Oncology, Boston, MA, USA.
Due to the significant morbidity and mortality of hemoglobinopathies, curative options have long been pursued. The overall goal of gene therapy is to modify a patient's own hematopoietic stem cells to overcome the deleterious effects of the underlying genetic defect by gene addition, gene editing, or gene silencing. Gene addition incorporates genes with superior function than the abnormal gene; gene editing takes advantage of molecular tools such as zinc finger proteins, Transcription Activator-Like Effector Nucleases and Clustered Regularly Interspaced Short Palindromic Repeats coupled with Cas9 proteins (CRISPR-Cas9) which allow for sequence-specific breaks in DNA that disrupt gene function; and gene silencing suppresses gene expression by interference with mRNA transcription/protein translation or epigenetic modification.
View Article and Find Full Text PDFEllagic Acid Exerts Dual Action to Curb the Pathophysiological Manifestations of Sickle Cell Disease and Attenuate the Hydroxyurea-Induced Myelosuppression in Berkeley Mice.
ACS Pharmacol Transl Sci
June 2023
Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
The use of adjuvant therapy is an attractive approach to manage sickle cell disease (SCD) symptomatically. The present study aimed to investigate the potential of ellagic acid as an adjuvant therapy with hydroxyurea (HU), a key drug for SCD with myelosuppressive toxic effects. A panel of experiments was performed using SCD patient's blood (ex vivo) and transgenic mice model of SCD (in vivo).
View Article and Find Full Text PDFEvaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells.
Cells
April 2023
Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador 40296-710, Brazil.
Background: Sickle cell disease (SCD) is a highly prevalent genetic disease caused by a point mutation in the gene, which can lead to chronic hemolytic anemia and vaso-occlusive events. Patient-derived induced pluripotent stem cells (iPSCs) hold promise for the development of novel predictive methods for screening drugs with anti-sickling activity. In this study, we evaluated and compared the efficiency of 2D and 3D erythroid differentiation protocols using a healthy control and SCD-iPSCs.
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