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KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid.
Nat Microbiol
January 2025
Department of Molecular Microbiology, John Innes Centre, Norwich, UK.
Examples of long-range gene regulation in bacteria are rare and generally thought to involve DNA looping. Here, using a combination of biophysical approaches including X-ray crystallography and single-molecule analysis for the KorB-KorA system in Escherichia coli, we show that long-range gene silencing on the plasmid RK2, a source of multi-drug resistance across diverse Gram-negative bacteria, is achieved cooperatively by a DNA-sliding clamp, KorB, and a clamp-locking protein, KorA. We show that KorB is a CTPase clamp that can entrap and slide along DNA to reach distal target promoters up to 1.
View Article and Find Full Text PDFUnravelling biotic and abiotic mechanisms of mature compost to alleviate gaseous emissions in kitchen waste composting by metagenomic analysis.
Bioresour Technol
January 2025
Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China. Electronic address:
Mature compost can reduce gaseous emissions in composting, but its regulation mechanisms via biotic and abiotic functions are largely unknown. This study used fresh and inactivated mature compost as additives in kitchen waste composting to unveil the relevant mechanisms using metagenomic analysis. Results showed that mature compost reduce gaseous emission by improving physiochemical properties and inoculating functional microbes.
View Article and Find Full Text PDFSmall intestinal bacterial overgrowth in chronic liver disease: an updated systematic review and meta-analysis of case-control studies.
EClinicalMedicine
February 2025
Faculty of Medicine, University of Queensland, Australia.
Background: Small Intestinal Bacterial Overgrowth (SIBO) has been implicated in the pathophysiology of chronic liver disease (CLD). We conducted a systematic review and meta-analysis to assess and compare the prevalence of SIBO among CLD patients (with and without with complications of end stage liver disease) and healthy controls.
Methods: Electronic databases were searched from inception up to July-2024 for case-control studies reporting SIBO in CLD.
Advancements and challenges of onboard carbon capture and storage technologies for the maritime industry: a comprehensive review.
Mar Syst Ocean Technol
January 2025
CMMI-Cyprus Marine & Maritime Institute, CMMI House-Vasileos Pavlou Square, P.O. Box 40930, 6023 Larnaca, Cyprus.
In response to the growing demand of reducing greenhouse gas (GHG) emissions within maritime sector, Onboard Carbon Capture and Storage (OCCS) technologies provide as key solutions for tackling carbon dioxide (CO) emissions from ships. This review paper offers a comprehensive overview of recent developments, challenges, and prospects of Carbon Capture and Storage (CCS) technologies considering specifically for onboard ship applications. Various Carbon Capture (CC) methods, ranging from post-combustion and pre-combustion capture to oxy-fuel combustion, are critically analysed concerning their operating principles, advantages, disadvantages and applicability in the maritime context.
View Article and Find Full Text PDFA Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants.
Adv Healthc Mater
January 2025
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Here a bioengineered platform is introduced to investigate adverse effects of environmental materials on the human cornea. Using primary cells, this system is capable of reproducing the differentiated corneal epithelium and its underlying stroma in the human eye, which can then be treated with externally applied solid, liquid, or gaseous substances in a controlled manner and under physiologically relevant conditions. The proof-of-principle of how this system can be used to simulate human ocular exposure to different classes of environmental toxicants for direct visualization and quantitative analysis of their potential to induce acute corneal injury and inflammation is demonstrated.
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