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Germline Single-Nucleotide Polymorphism Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia.
Biomedicines
January 2025
Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.
: GFI1-36N represents a single-nucleotide polymorphism (SNP) of the zinc finger protein Growth Factor Independence 1 (GFI1), in which the amino acid serine (S) is replaced by asparagine (N). The presence of the gene variant is associated with a reduced DNA repair capacity favoring myeloid leukemogenesis and leads to an inferior prognosis of acute myeloid leukemia (AML) patients. However, the underlying reasons for the reduced DNA repair capacity in leukemic cells are largely unknown.
View Article and Find Full Text PDFA Comprehensive Review of Phenolic Compounds in Chia Seeds and Their Applications in the Food Industry.
Plant Foods Hum Nutr
January 2025
Department of Food Science, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Chia seeds (Salvia hispanica L.) have emerged as a significant focus in the food industry due to their rich nutritional profile and health-promoting attributes. They are a major powerhouse of bioactive compounds such as flavonoids, phenolic acids, and tocopherols that have been shown to possess anti-inflammatory, anti-diabetic, anti-cholesterol functions, enhance cognitive performance, and improve heart health.
View Article and Find Full Text PDFGreen solid lipid nanoparticles by coacervation of fatty acids: An innovative cosmetic ingredient for the delivery of anti-age compounds through the skin.
Int J Pharm
January 2025
University of Turin, Department of Drug Science and Technology, via Pietro Giuria 9, 10125 Turin, Italy; University of Turin, Department of Medical Sciences, Dermatologic Clinic, Via Cherasco 23, 10126 Turin, Italy.
The constant exposure of the skin to internal and external stimuli drives towards skin aging and lost in skin hydration and elasticity. Chronic low-grade inflammation, called inflammaging, and oxidative stress are the leading causes of this phenomenon. Fatty acid coacervation is a preparation method for Solid Lipid Nanoparticles (SLNs), which does not employ solvents, and is associated to low energy consumption.
View Article and Find Full Text PDFFlaxseed and olive oil effectively treat numerous diseases and health conditions, particularly metabolic disorders. Traditional medicine has used both oils for managing cardiovascular disease, diabetes, gastrointestinal dysfunctions, metabolic-dysfunction-associated fatty liver disease (MAFLD), obesity, and more. This review explores the bioactive and polyphenolic compounds in flaxseed and olive oils that provide anti-inflammatory, antioxidant, anti-microbial, hepatoprotective, cardioprotective, antidiabetic, and gastroprotective benefits.
View Article and Find Full Text PDFPlatelet Mitochondrial Function and Endogenous Coenzyme Q Levels Could Be Used as Markers of Mitochondrial Health in Infertile Men: A Pilot Study.
Int J Mol Sci
December 2024
Faculty of Medicine, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Fertility disorders are a worldwide problem affecting 8-12% of the population, with the male factor substantially contributing to about 40-50% of all infertility cases. Mitochondria, crucial organelles for cellular viability, play a pivotal role in the processes of spermatogenesis and significantly affect sperm quality and their fertilizing ability. Mitochondrial oxidative phosphorylation (OXPHOS) dysfunction, reduced energy supply for sperm, reduced endogenous coenzyme Q (CoQ) levels, and oxidative stress are among the main factors that contribute to male infertility.
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