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Real-world satisfaction and experience with injection and autoinjector device for ofatumumab indicated for multiple sclerosis.
BMC Neurol
January 2025
Real World Solutions, IQVIA, 2400 Ellis Road, Durham, NC, 27703, USA.
Background: To evaluate the overall satisfaction, device usability, and injection experience of MS patients self-administering ofatumumab using the Sensoready autoinjector device in the United States (US).
Methods: This US-based, cross-sectional survey study included patients with MS (≥ 18 years) who self-administered ofatumumab using the Sensoready device within the previous 12 months of the survey. Eligible patients were administered a 30-item de novo questionnaire that focused on overall device satisfaction, device usability, convenience/flexibility for travel with the device, user confidence, injection experience, and time to administer the injection.
The effect of instructional therapeutic play on acceptance behavior of nasal lavage in hospitalized children.
J Pediatr Nurs
December 2024
School of Nursing, University of São Paulo, São Paulo, Brazil.
Purpose: To evaluate the effect of instructional therapeutic play on acceptance of nasal lavage in children hospitalized for respiratory conditions.
Design And Methods: This quasi-experimental study was conducted at a teaching hospital. For the therapeutic play session, disposable gloves filled with compressed air and designed to resemble a human face, syringes, and saline solution ampoules were used.
A Feasibility Trial on Intranasal Evaporative Cooling for Acute Migraine in an At-Home Setting.
Cureus
November 2024
Department of Clinical Sciences, Lund University, Malmö, SWE.
Article Synopsis
- - The study aimed to assess the feasibility of self-administering intranasal evaporative cooling for acute migraine relief at home, following previous success in a clinic setting.
- - Conducted in southern Sweden, the trial involved 15 participants with episodic migraine, but only 6 completed the study due to discomfort and ineffective results.
- - Findings indicated that the treatment was largely considered unpleasant and not significantly more effective than existing care methods, leading to the conclusion that it is not a viable option for home use.
Mechanical acupuncture at HT7 attenuates alcohol self-administration in rats by modulating neuroinflammation and altering mPFC-habenula-VTA circuit activity.
Front Behav Neurosci
October 2024
Department of Oriental Medicine Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Introduction: Alcohol use disorder is a chronic disorder with significant limitations in pharmacological treatments, necessitating the exploration of non-pharmacological interventions.
Methods: We used a model of alcohol self-administration (10% v/v) to analyze behavioral, neurochemical, and signaling mechanisms.
Results: Our findings demonstrate that stimulation of the HT7 acupuncture point significantly decreased the frequency of active lever presses in rats self-administering alcohol ( < 0.
Preclinical evaluation of abuse potential of the peripherally-restricted kappa opioid receptor agonist HSK21542.
Regul Toxicol Pharmacol
December 2024
Saifu Laboratories Co., Ltd., Beijing, China; SAFE Medical Technology Co., Ltd., Hebei, China. Electronic address:
Article Synopsis
- HSK21542 is a kappa opioid receptor (KOR) agonist designed for pain relief and has been assessed for its potential for abuse prior to approval.
- The preclinical studies involved various tests in rats, including self-administration, drug discrimination, conditioned place preference, and withdrawal assessments, to evaluate its reinforcing effects and dependence potential.
- Results indicated that HSK21542 showed no behavioral signs of abuse or dependence, suggesting it has a low potential for abuse in humans.
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