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Estimating the Exposure-Response Relationship between Fine Mineral Dust Concentration and Coccidioidomycosis Incidence Using Speciated Particulate Matter Data: A Longitudinal Surveillance Study.
Environ Health Perspect
January 2025
Department of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Nevada, Reno, Reno, Nevada, USA.
Background: Coccidioidomycosis, caused by inhalation of spp. spores, is an emerging infectious disease that is increasing in incidence throughout the southwestern US. The pathogen is soil-dwelling, and spore dispersal and human exposure are thought to co-occur with airborne mineral dust exposures, yet fundamental exposure-response relationships have not been conclusively estimated.
View Article and Find Full Text PDFEfficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways.
J Vis Exp
December 2024
Department of Medicine, New Jersey Medical School, Rutgers - The State University of New Jersey;
Fungi infect humans when environmental spores are inhaled into the lungs. The lung is a heterogeneous organ. Conducting airways, including bronchi and bronchioles, branch until terminating in the alveolar airspace where gas exchange occurs.
View Article and Find Full Text PDFDisseminated histoplasmosis from western Mexico-rethinking our geographic distribution of endemic fungal species: a case report and review of literature.
J Med Case Rep
November 2024
Division of Pediatric Infectious Diseases, Memorial Care Miller Children's & Women's Hospital Long Beach, Clinical Professor of Pediatrics, University of California Irvine Department of Pediatrics, Irvine, CA, USA.
Background: Histoplasma is a fungal pathogen found in many parts of the world. In North America, its distribution is traditionally thought to be endemic to the Ohio and Mississippi River valleys. Development of histoplasmosis after Histoplasma exposure is related to degree of inoculum exposure and susceptibility, for example, immunocompromised status.
View Article and Find Full Text PDFProlonged dry seasons lengthen coccidioidomycosis transmission seasons: implications for a changing California.
medRxiv
October 2024
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Coccidioidomycosis, a fungal disease caused by soil-borne spp., exhibits pronounced seasonal transmission, with incidence in California typically peaking in the fall. However, the influence of climate on the timing and duration of transmission seasons remains poorly understood.
View Article and Find Full Text PDFCharacterizing the soil microbial community associated with the fungal pathogen .
bioRxiv
September 2024
Division of Environmental Health Sciences, University of California, Berkeley, Berkeley, California, 94720.
Article Synopsis
- * A study conducted in Carrizo Plain National Monument found that soil microbial communities, particularly in rodent burrows, showed a higher diversity and a significant association with the presence of the pathogen compared to surface soils.
- * Results indicated that soil from rodent burrows had greater microbial diversity, suggesting that these environments may enhance the presence of the pathogen, challenging previous assumptions about microbial diversity and its relation to Coccidioidomycosis.
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