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Eur Thyroid J
January 2025
D Villagelin, PUC-Campinas, Campinas, Brazil.
Background: Thyroid eye disease (TED) is the most prevalent extrathyroidal manifestation of Graves' disease (GD). Emerging evidence suggests a relationship between elevated total and LDL cholesterol levels and TED. This study aimed to investigate this correlation in the Brazilian population by analyzing data from two tertiary care centers.
View Article and Find Full Text PDFBMC Endocr Disord
August 2022
Department of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, 5758 S. Maryland Ave, Chicago, IL, 60637, USA.
Background: Graves' disease (GD) and papillary thyroid cancer (PTC) can be concomitant. The existence of a link between these entities has long been investigated, but a clear correlation hasn't been established. We report a case of GD resistant to medical treatment in which surgery revealed unsuspected PTC and we aim to study the prevalence of PTC in Graves' disease, its clinical characteristics and review of the literature.
View Article and Find Full Text PDFExpert Rev Endocrinol Metab
March 2022
Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Introduction: Graves' disease (GD) is an autoimmune disorder due to loss of tolerance to the thyrotropin receptor (TSHR) and ultimately caused by stimulatory TSHR antibodies (TSHR-Ab). GD may be associated with extrathyroidal manifestations, mainly Graves' orbitopathy. Treatment of GD relies on antithyroid drugs (ATDs), radioactive iodine (RAI), thyroidectomy.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
December 2020
Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.
Context: Invited update on the management of systemic autoimmune Graves disease (GD) and associated Graves orbitopathy (GO).
Evidence Acquisition: Guidelines, pertinent original articles, systemic reviews, and meta-analyses.
Evidence Synthesis: Thyrotropin receptor antibodies (TSH-R-Abs), foremost the stimulatory TSH-R-Abs, are a specific biomarker for GD.
Objective: The objective of this report was to describe a patient with Graves acropachy, a rare manifestation of Graves disease (GD) that is clinically defined by skin tightness, digital clubbing, small-joint pain, and soft tissue edema progressing over months or years with gradual curving and enlargement of the fingers.
Methods: The patient was evaluated regarding thyroid function (serum free T4 [FT4] and thyroid-stimulating hormone [TSH] quantifications) and autoimmunity biomarkers (thyroid receptor antibody [TRAb]) as well as radiographic investigation of the extremities.
Results: A 52-year-old man presented with a history of thyrotoxicosis and clinical signs of Graves orbitopathy.
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