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How polycystic ovary syndrome came into its own.

F S Sci

February 2021

Department of Health Policy, Management and Behavior, School of Public Health, State University of New York at Albany, Albany, New York; Department of Obstetrics and Gynecology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Polycystic ovary syndrome (PCOS) is a disorder whose definition and diagnosis have been evolving over the past 85 years since Stein and Leventhal made their original description of the triad of amenorrhea, polycystic ovaries, and hyperandrogenism in 1935. Although much progress in characterizing the disorder was accomplished from the late 1950s through the late 1980s, much confusion remained in the field, as there were no agreed-upon diagnostic criteria. This deficiency began to be addressed with a conference held at the National Institutes of Health (NIH) in April 1990, which, through a survey of meeting participants, defined what is today known as "classic" PCOS.

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, and recently, chromium was discussed as an adjuvant way to manage it. Herein, a systematic review was conducted which centered on the effects of chromium on ovarian physiology with a focus on body mass index, as well as hormonal and metabolic dysfunctions in women suffering from PCOS. This review was performed using the guidelines from Preferred Reporting Items for Systematic Reviews.

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Sex hormone profile and morphological changes in the ovaries in chronic endotoxicosis.

Bull Exp Biol Med

July 2010

Laboratory of Basic Studies, Volgograd Research Center, Russian Academy of Medical Sciences and Administration of the Volgograd Region, Moscow, Russia.

Morphological changes in the ovaries and levels of sex hormones were studied in rats with chronic endotoxicosis. Long-term endogenous intoxication was associated with the development of sclerocystic ovary syndrome paralleled by hormone imbalance.

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The authors operated 155 women where ovarian dysfunction was the cause of infertility. The first group was formed by 125 women with the Stein-Leventhal syndrome, the second group was formed by 30 women with dysgenesis of the gonads, karyotype, 46,XX. In the first group 97 of the operated women (77.

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