Similar Publications
Vulvar dermatofibrosarcoma protuberans masquerading as angiomyxoma: A case report and review of 85 cases.
Indian J Pathol Microbiol
March 2025
Department of Obstetrics and Gynecology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous mesenchymal locally aggressive sarcoma with high recurrence. We report a case of recurrent vulvar DFSP, and a literature review was performed with a PubMed search using the terms "Dermatofibrosarcoma protuberans" and "vulva." Total 85 cases with vulvar DFSP were analyzed for their clinicopathological features among fibrosarcomatous DFSP (FS-DFSP) and non-FS-DFSP.
View Article and Find Full Text PDFEpithelial-Myoepithelial Carcinoma of the Submandibular Gland Arising from Recurrent Pleomorphic Adenoma: A Rare Case Report.
Ear Nose Throat J
March 2025
ENT Department and Cervical Surgery Farhat Hached Hospital, Medicine University, Sousse, Tunisia.
A 36-year-old male with a history of smoking presented with recurrent right submandibular swelling. Initially diagnosed with pleomorphic adenoma, he underwent total submandibulectomy. After 2 years, he developed a recurrent submandibular mass.
View Article and Find Full Text PDFPretreatment Liquid Biopsy and Clinicopathologic Features in HPV-Associated Oropharyngeal Squamous Cell Carcinoma.
JAMA Otolaryngol Head Neck Surg
March 2025
Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
Importance: Despite the favorable prognosis for HPV-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC), efforts to de-escalate treatment intensity, while maintaining low recurrence and mortality rates, have proven challenging. Identifying appropriate prognostic factors remains elusive; however, the association of pretreatment circulating tumor tissue viral-modified HPV (TTMV-HPV) DNA level with known characteristics of disease burden-clinical staging, characteristics of pretreatment imaging, and aggressive histopathologic features of surgical specimen-may offer insights that could shift treatment paradigms for HPV+ OPSCC.
Objective: To investigate the association of pretreatment TTMV-HPV DNA levels with clinical, radiologic, histopathologic, and outcome metrics in patients with HPV+ OPSCC.
Importance: Treating locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) involves any combination of surgery, radiation, and chemotherapy, followed by routine monitoring for local recurrence or distant metastases. Given the poor patient outcomes, a significant unmet clinical need for improved treatment options remains.
Objective: To evaluate efficacy and safety of maintenance atezolizumab in patients with LA SCCHN at high risk of disease progression after multimodal definitive treatment.
Prognostic significance of Ki-67 in assessing the risk of progression, relapse or metastasis in pheochromocytomas and paragangliomas.
Ann Med
December 2025
Cancer Center, The First Hospital of Jilin University, Changchun, China.
Introduction: Since the Fourth edition of the WHO classification, PPGLs have been recognized for their metastatic potential, though no clear features can accurately predict this behavior. The prognostic value of Ki-67 in assessing the risk of progression, relapse, or metastasis in PPGLs remains debated.
Methods: This cohort study included 501 patients diagnosed with PPGLs at the First Hospital of Jilin University between 2000 and 2022, with clinical data, treatment details, pathological indicators, and germline gene test results collected.
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