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The influence of sociodemographic and health factors on adherence to home-based rehabilitation after fast-track total knee arthroplasty: secondary analysis of a randomized controlled trial.
Disabil Rehabil
January 2025
Clinic Institute of Medical and Surgical Specialties (ICEMEQ), Hospital Clinic of Barcelona, Barcelona, Spain.
Purpose: Adherence to home rehabilitation following total knee arthroplasty (TKA) is essential to reach optimal functional outcomes, especially in fast-track procedures. The aim of this study is to identify which sociodemographic and health factors significantly affect adherence in this context.
Methods: This is a secondary analysis of a randomized controlled trial with 52 patients.
Characterization of pharmaceutical services in the prison system: cross-sectional study.
Cien Saude Colet
January 2025
Programa de Pós-Graduação em Assistência Farmacêutica, Universidade Federal do Rio Grande do Sul. R. São Luís 150, Santana. 90620-170 Porto Alegre RS Brasil.
Article Synopsis
- The study assessed the organization and infrastructure of pharmaceutical services in the prison system of Rio Grande do Sul, identifying major deficiencies in the primary health care framework.
- Most prison units lacked designated pharmacy areas and standardized procedures, with 78.4% reporting no operational guidelines for pharmacy activities.
- Only a small percentage had a pharmacist on site, and many did not adequately monitor medication storage conditions or have proper medication dispensing processes in place, highlighting significant weaknesses in the system.
Targeting AXL inhibits the growth and metastasis of prostate cancer in bone.
Clin Cancer Res
January 2025
Stanford University, Palo Alto, CA, United States.
Purpose: After failing primary and secondary hormonal therapy, castration-resistant and neuroendocrine prostate cancer metastatic to the bone is invariably lethal, although treatment with docetaxel and carboplatin can modestly improve survival. Therefore, agents targeting biologically relevant pathways in PCa and potentially synergizing with docetaxel and carboplatin in inhibiting bone metastasis growth are urgently needed.
Experimental Design: Phosphorylated (activated) AXL expression in human prostate cancer bone metastases was assessed by immunohistochemical staining.
Strategies and Prospects for Engineering a Stable Zn Metal Battery: Cathode, Anode, and Electrolyte Perspectives.
Acc Chem Res
January 2025
Department of Chemistry, Shanghai Key Laboratory of Catalysis and Innovative Materials, Center of Chemistry for Energy Materials Shanghai, Fudan University, Shanghai 200433, PR China.
ConspectusZinc metal batteries (ZMBs) appear to be promising candidates to replace lithium-ion batteries owing to their higher safety and lower cost. Moreover, natural reserves of Zn are abundant, being approximately 300 times greater than those of Li. However, there are some typical issues impeding the wide application of ZMBs.
View Article and Find Full Text PDFRole of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding.
ACS Infect Dis
January 2025
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a promising antibiotic target. This enzyme catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP), which is the rate-limiting step in guanine nucleotide biosynthesis. Bacterial IMPDH-specific inhibitors have been developed that bind to the NAD site.
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