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Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Front Immunol
October 2021
Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.
Background: Vaginal adenocarcinomas (VAC) are most often reported after intrauterine exposition to diethylstilbestrol (DES). Rarely, VACs are reported as a malignant transformation of vaginal adenosis or endometriosis, in the context of chromosomal abnormalities or malformations of the uterus or the vagina. VACs without DES exposition have a poor prognosis and a significantly worse outcome compared to vaginal squamous cell carcinomas or DES-associated VACs.
View Article and Find Full Text PDFGiant primary vaginal tubulovillous adenoma: A case report and review of literature.
Urol Case Rep
September 2021
Department of Urology, MedStar Georgetown University Hospital, Washington, DC, USA.
Primary adenomas are common in the gastrointestinal tract but exceedingly rare on the periurethral surface and vagina. The pathogenesis remains unknown but vaginal adenomas are hypothesized to arise from vaginal adenosis or embryonic cloacal remnants and possess malignant potential. We present a case of a large primary vaginal tubulovillous adenoma in an eighty-one-year-old, likely diethylstilbestrol naïve patient.
View Article and Find Full Text PDFTransperineal Ultrasonographic and Magnetic Resonance Imaging Findings of Vaginal Adenosis.
Curr Med Imaging
April 2022
Department of Obstetrics and Gynecology, Faculty of Medicine Ataturk Training and Research Hospital, Kâtip Celebi University, Izmir, Turkey.
Background: Vaginal adenosis is a rare clinicopathological entity which refers to the presence of glandular endometrial tissue in the vaginal wall.
Case Report: A gravida 2 para 0 46-year-old woman presented to the gynecology department with symptoms of chronic pelvic pain. Maternal Diethylstilbestrol (DES) usage has been proven to be effective in the development of vaginal adenosis.
A case of vaginal adenosis with gastric differentiation.
Gynecol Oncol Rep
November 2020
Department of Obstetrics and Gynecology, New York University Langone Health, 660 First Ave, New York, NY, 10016, USA.
•Vaginal adenosis is a non-obligate pre-cursor for vaginal clear cell carcinoma.•Vaginal adenosis is rare and presents with a variety of signs and symptoms.•Unclear link between adenosis and carcinoma without diethylstilbestrol exposure.
View Article and Find Full Text PDFPrimary vaginal clear cell adenocarcinoma accompanied by Herlyn-Werner-Wunderlich syndrome without prenatal diethylstilbestrol exposure: a case report.
Int J Clin Exp Pathol
November 2020
Department of Gynecology, West China Second Hospital of Sichuan University Chengdu 610041, Sichuan, China.
We report a rare case of a 40 years old woman with primary vaginal clear cell adenocarcinoma (CCA) accompanied by Herlyn-Werner-Wunderlich syndrome (HWWS) and without any prenatal diethylstilbestrol exposure. Pathological results indicated that the CCA was surrounded by adenosis and that there was a benign to malignant transformation of several glands in the epithelium, so the CCA was believed to have arisen from the adenosis. The literature review disclosed that genitourinary anomalies might be associated with an increased risk of adenocarcinoma, but the mechanism was not clear.
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