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Technical note: utilization of various allotment strategies to evaluate variation and replications required to detect statistical significance in nursery pig research.
J Anim Sci
January 2024
Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS 66506-0201, USA.
A total of 720 barrows (line 200 × 400, DNA genetics) were used in two 42-d nursery trials (initially 6.20 ± 0.12 kg and 5.
View Article and Find Full Text PDFAdvances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides.
Chem Res Toxicol
April 2024
NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100017, People's Republic of China.
Article Synopsis
- Quinoxaline 1,4-di-N-Oxides (QdNOs) are synthetic antimicrobial agents used in livestock and fish farming, but their metabolism and potential toxicity have raised concerns.
- Research identified multiple metabolites for several QdNOs, with specific markers associated with metabolic processes like N → O reduction.
- Toxicity studies indicate that QdNOs and their metabolites can cause significant health issues, including tumor development, and some metabolites may even be more toxic than their original compounds, emphasizing the need for further research and food safety assessments.
Determination of marker residues of quinoxaline-1,4-di-N-oxides and its prototype identification by liquid chromatography tandem mass spectrometry.
Food Chem
June 2024
Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, Guangzhou 510642, China; Inspection and Testing Center for Domestic Animal Products (Guangzhou), Ministry of Agriculture and Rural Affairs, Guangzhou 510642,China; National Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Quinoxaline-1,4-di-N-oxides (QdNOs), such as carbadox, olaquindox, mequindox, quinocetone, etc. are a class of antibacterial drugs. Prototype drugs residues can not be detected due to their rapid metabolism in animals.
View Article and Find Full Text PDFEvaluation of protected benzoic acid on growth performance, nutrient digestibility, and gut health indices in starter pigs.
Transl Anim Sci
September 2023
Department of Animal Sciences, Auburn University, Auburn, AL 36849, USA.
Benzoic acid is a common alternative for antibiotic and zinc oxide use in nursery diets. Free benzoic acid () is often supplied, but this form is absorbed before it can exert any effect on distal segments of the gut. The study aimed to evaluate the effects of protected benzoic acid on growth performance, nutrient digestibility, plasma metabolites, and gut health indices in starter pigs.
View Article and Find Full Text PDFUrinary antibiotic concentrations in preschool children from eastern China and health risk assessment.
Environ Sci Pollut Res Int
July 2023
Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 172, Gulou District, Nanjing, 210000, Jiangsu, China.
Despite limited biomonitoring studies suggesting extensive antibiotic exposure in general population, the body burden of antibiotics in young children and their potential health risks remain unclear. To assess the antibiotic exposure levels in young children, 508 preschoolers aged 3-6 years were recruited from eastern China in 2022, and a total of 50 representative antibiotics from 8 categories, including 17 human antibiotics (HAs), 4 antibiotics preferred as HAs (PHAs), 16 veterinary antibiotics (VAs), and 13 antibiotics preferred as VAs (PVAs), were analyzed by UPLC-MS/MS. Hazard quotient (HQ) and hazard index (HI) were calculated to evaluate the health risks, and multivariate logistic regression was applied to examine diet with antibiotic exposure.
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