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Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma.
BMC Biol
January 2025
Faculty of Biology, Johannes Gutenberg University Mainz, Mainz, Germany.
Background: Glioblastoma multiforme (GBM) is characterized by its cellular complexity, with a microenvironment consisting of diverse cell types, including oligodendrocyte precursor cells (OPCs) and neoplastic CD133 + radial glia-like cells. This study focuses on exploring the distinct cellular transitions in GBM, emphasizing the role of alternative polyadenylation (APA) in modulating microRNA-binding and post-transcriptional regulation.
Results: Our research identified unique APA profiles that signify the transitional phases between neoplastic cells and OPCs, underscoring the importance of APA in cellular identity and transformation in GBM.
Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis.
BMC Med
January 2025
Department of Cardiothoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Background: Current research underscores the need to better understand the pathogenic mechanisms and treatment strategies for idiopathic pulmonary fibrosis (IPF). This study aimed to identify key targets involved in the progression of IPF.
Methods: We employed Mendelian randomization (MR) with three genome-wide association studies and four quantitative trait loci datasets to identify key driver genes for IPF.
Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches.
BMC Med
January 2025
PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Background: Maternal stress during pregnancy may impact offspring development via changes in the intrauterine environment. However, genetic and environmental factors shared between mothers and children might skew our understanding of this pathway. This study assesses whether prenatal maternal stress has causal links to offspring outcomes: birthweight, gestational age, or emotional and behavioral difficulties, triangulating across methods that account for various measured and unmeasured confounders.
View Article and Find Full Text PDFTranscriptomic dynamics and cell-to-cell communication during the transition of prospermatogonia to spermatogonia revealed at single-cell resolution.
BMC Genomics
January 2025
Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, 810008, China.
Background: Spermatogonia are essential for the continual production of sperm and regeneration of the entire spermatogenic lineage after injury. In mammals, spermatogonia are formed in the neonatal testis from prospermatogonia (also termed gonocytes), which are established from primordial germ cells during fetal development. Currently, the molecular regulation of the prospermatogonial to spermatogonia transition is not fully understood.
View Article and Find Full Text PDFGenome-wide identification, characterization and expression analysis of WRKY transcription factors under abiotic stresses in Carthamus tinctorius L.
BMC Plant Biol
January 2025
Institute of Chinese Herbel Medicines, Henan Academy of Agricultural Sciences, Zhengzhou , Henan, 450002, China.
Background: WRKY transcription factors constitute one of the largest families of plant transcriptional regulators, playing pivotal roles in plant responses to biotic and abiotic stresses, as well as in hormonal signaling and secondary metabolism regulation. However, a comprehensive analysis of the WRKY family in Carthamus tinctorius (safflower) is lacking. This study aims to identify and characterize WRKY genes in safflower to enhance understanding of their roles in stress responses and metabolic regulation.
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