Toxic megacolon.

Dis Colon Rectum

Published: December 1973

Download full-text PDF

Source
http://dx.doi.org/10.1007/BF02587588DOI Listing

Publication Analysis

Top Keywords

toxic megacolon
4
toxic
1

Similar Publications

Acute severe ulcerative colitis: defining the precise moment for colectomy.

Expert Rev Gastroenterol Hepatol

January 2025

INFINY Institute, Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, Vandœuvre-lès-Nancy, France.

Introduction: Acute severe ulcerative colitis (ASUC) is a critical manifestation of ulcerative colitis (UC), often necessitating colectomy when medical management fails. Despite advancements in therapeutic interventions such as corticosteroids, biologics, and JAK inhibitors, a significant proportion of patients require surgery, with colectomy rates ranging from 10% to 15%.

Areas Covered: This paper reviews the factors influencing the timing and necessity of colectomy in ASUC management, emphasizing the importance of multidisciplinary decision-making involving gastroenterologists and surgeons.

View Article and Find Full Text PDF
Article Synopsis
  • - Ameboma is a rare complication from invasive amebiasis caused by a specific intestinal protozoan, leading to tumor-like inflammatory masses in the lower right abdomen.
  • - Symptoms can vary but often include intestinal obstruction and gastrointestinal bleeding, and while imaging techniques like CT and ultrasound can reveal colonic masses, biopsy remains the most reliable way to diagnose ameboma.
  • - Treatment generally involves targeting the protozoan causing the infection, with surgery being necessary for severe cases like intestinal obstruction or other serious complications.
View Article and Find Full Text PDF

Fulminant colitis is a severe and potentially life-threatening form of associated bacterial disease leading to inflammation and damage to the colon. Complications such as toxic megacolon, sepsis, and multi-organ failure commonly occur in individuals with compromised immune systems and recent antibiotic use. Management of colitis involves optimization of fluid and electrolyte balance, and elimination of bacteria commonly by administering vancomycin or fidaxomicin.

View Article and Find Full Text PDF

In recent years, there has been a significant rise in both the frequency and severity of colitis. This infection presents a broad clinical spectrum, ranging from asymptomatic colonization to severe fulminant colitis, which often requires urgent surgical intervention. The failure of medical treatments and the development of toxic megacolon typically necessitate surgery, though it is associated with high mortality rates.

View Article and Find Full Text PDF
Article Synopsis
  • - The case report highlights a rare instance of urolithiasis (kidney stones) related to the metabolite N4-acetyl-sulfamethoxazole, following prolonged treatment with trimethoprim/sulfamethoxazole (TMP-SMX).
  • - The patient had undergone a total colectomy and had a history of benign prostatic hypertrophy and chronic urinary retention, which contributed to metabolic conditions that increased the risk of stone formation.
  • - The stones were analyzed using light microscopy and scanning electron microscopy (SEM), revealing rectangular-shaped crystals, marking the first time such crystals have been characterized using SEM.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!