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Model-based analysis of the acute effects of transcutaneous magnetic spinal cord stimulation on micturition after spinal cord injury in humans.
PLoS Comput Biol
July 2024
Department of Mechanical Engineering, University of California, Los Angeles, California, United States of America.
Aim: After spinal cord injuries (SCIs), patients may develop either detrusor-sphincter dyssynergia (DSD) or urinary incontinence, depending on the level of the spinal injury. DSD and incontinence reflect the loss of coordinated neural control among the detrusor muscle, which increases bladder pressure to facilitate urination, and urethral sphincters and pelvic floor muscles, which control the bladder outlet to restrict or permit bladder emptying. Transcutaneous magnetic stimulation (TMS) applied to the spinal cord after SCI reduced DSD and incontinence.
View Article and Find Full Text PDFSimple model to incorporate statistical noise based on a modified hodgkin-huxley approach for external electrical field driven neural responses.
Biomed Phys Eng Express
June 2024
Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, 79409, United States of America.
Noise activity is known to affect neural networks, enhance the system response to weak external signals, and lead to stochastic resonance phenomenon that can effectively amplify signals in nonlinear systems. In most treatments, channel noise has been modeled based on multi-state Markov descriptions or the use stochastic differential equation models. Here we probe a computationally simple approach based on a minor modification of the traditional Hodgkin-Huxley approach to embed noise in neural response.
View Article and Find Full Text PDFRepresentation of single neuron dynamics using 1-D and 2-D Discrete dynamical systems.
Biomed Phys Eng Express
July 2023
Sinan Kapçak, College of Engineering and Technology, American University of the Middle East, Kuwait.
Biological neurons are typically modeled using the Hodgkin-Huxley formalism, which requires significant computational power to simulate. However, since realistic neural network models require thousands of synaptically coupled neurons, a faster approach is needed. Discrete dynamical systems are promising alternatives to continuous models, as they can simulate neuron activity in far fewer steps.
View Article and Find Full Text PDFThe effects of membrane potential oscillations on the excitability of rat hypoglossal motoneurons.
Front Physiol
August 2022
Department of Physiology & Biophysics, School of Medicine, University of Washington, Seattle, WA, United States.
Oscillations in membrane potential induced by synaptic inputs and intrinsic ion channel activity play a role in regulating neuronal excitability, but the precise mechanisms underlying their contributions remain largely unknown. Here we used electrophysiological and modeling approaches to investigate the effects of Gaussian white noise injected currents on the membrane properties and discharge characteristics of hypoglossal (HG) motoneurons in P16-21 day old rats. We found that the noise-induced membrane potential oscillations facilitated spike initiation by hyperpolarizing the cells' voltage threshold by 3.
View Article and Find Full Text PDFA computational modelling study of excitation of neuronal cells with triboelectric nanogenerators.
Sci Rep
August 2022
Department of Medical Physics and Biomedical Engineering, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neurological disorders and nerve injuries, such as spinal cord injury, stroke, and multiple sclerosis can result in the loss of muscle function. Electrical stimulation of the neuronal cells is the currently available clinical treatment in this regard. As an effective energy harvester, the triboelectric nanogenerators (TENG) can be used for self-powered neural/muscle stimulations because the output of the TENG provides stimulation pulses for nerves.
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