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Early Positive Report of Viloxazine for a Child with Hyperkinetic Autism.
Psychopharmacol Bull
January 2025
Alamiri, MD, ABPN, ScD, Al-Manara CAP Centre, Kuwait Centre for Mental Health (KCMH), Shuwaikh, State of Kuwait.
Herein, authors report on an ASD child with comorbid ADHD, ID, metabolic syndrome and nocturnal enuresis that failed multiple trials of psychotropic agents for behavioural dyscontrol. Viloxazine adjuventia brought about remarkable improvement spanning different domains. Purported pharmacodynamic mechanisms are briefly discussed.
View Article and Find Full Text PDFRhynchophylline Alleviates Hyperactivity and Cognitive Flexibility Impairment Associated With Inhibition of Inflammatory Responses in Mice That Partly Lack the Dopamine Transporter Protein.
Brain Behav
November 2024
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York, USA.
Article Synopsis
- Rhynchophylline (RHY), an active ingredient in Ningdong granule, is studied for its potential to alleviate hyperactivity and cognitive issues in ADHD and Tourette syndrome patients, although its mechanisms remain unclear.
- A study of male dopamine transporter knockout mice (DAT-) found that RHY treatment improved their hyperactivity and cognitive flexibility, evaluated through specific behavioral tests.
- RHY also reduced inflammatory markers in mouse brains and in cultured neuroinflammatory cells, indicating it may work by inhibiting inflammation.
Thromboembolic Complications in Takotsubo Cardiomyopathy.
Semin Thromb Hemost
October 2024
Department of Cardiology, Rambam Medical Center, and B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel.
Apical ballooning syndrome, commonly known as Takotsubo syndrome, is a distinct cardiomyopathy often resembling acute myocardial infarction in presentation. Takotsubo syndrome patients exhibit varied patterns of left ventricular wall motion abnormalities, most frequently apical dyskinesis with basal hyperkinesis, that are characteristically transient. Although emotional or physical stressors precipitate Takotsubo syndrome in most cases, a significant proportion presents without identifiable triggers, with a pronounced female predominance.
View Article and Find Full Text PDFTakotsubo syndrome complicated by cardiogenic shock due to left ventricular outflow tract obstruction, acute mitral regurgitation, and atrial fibrillation: a case report.
Eur Heart J Case Rep
August 2024
Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
Background: Although Takotsubo syndrome (TTS) is generally considered a benign disease, recent reports showed the incidence of cardiogenic shock due to left ventricular outflow tract obstruction (LVOTO), mitral regurgitation (MR), and primary pump failure was estimated to be 6-20%.
Case Summary: A 78-year-old woman presented with chest pain and cold sweats 2 days after surgery for lung cancer. Acute coronary syndrome was suspected based on her symptoms, electrocardiography, transthoracic echocardiography (TTE), and laboratory data; thus, emergency catheterization was performed.
Hyperkinesias in Leigh-like Syndrome with Complex-I Deficiency Due to m.10191T>C in MT-ND3.
Ann Afr Med
July 2024
Neurology and Neurophysiology Center, Vienna, Austria.
Hyperkinesias in a patient with complex-I deficiency due to the variant m.10191T>C in MT-ND3 have not been previously reported. The patient is a 32 years-old female with multisystem mitochondrial disease due to variant m.
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