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Nano-phytosome loaded Retama raetam extract/colistin: antibacterial, antioxidant activities and in vivo lipopolysaccharide-induced-neurotoxicity inhibition.
Braz J Microbiol
December 2024
Department of Botany & Microbiology, Faculty of Science, Alexandria University, Alexandria, 21568, Egypt.
Antibiotics are misused nowadays, leading to the prevalence of antibiotic resistant bacterial strains; causing the world to move towards natural medicine. Retama raetam had wide medicinal use. In the present study, R.
View Article and Find Full Text PDFEnvironmental conditions affect the nutritive value and alkaloid profiles of forage: Opportunities and threats for sustainable ruminant systems.
Heliyon
April 2024
REQUIMTE, LAQV, ICBAS, School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
The identification of crops that simultaneously contribute to the global protein supply and mitigate the effects of climate change is an urgent matter. Lupins are well adapted to nutrient-poor or contaminated soils, tolerate various abiotic stresses, and present relevant traits for acting as ecosystem engineers. Lupins are best studied for their seeds, but their full foraging potential needs further evaluation.
View Article and Find Full Text PDFFurther Quinolizidine Derivatives as Antiarrhythmic Agents- 3.
Molecules
October 2023
Food Chemistry and Nutraceutical Research Unit, Department of Pharmacy & Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Fourteen quinolizidine derivatives, structurally related to the alkaloids lupinine and cytisine and previously studied for other pharmacological purposes, were presently tested for antiarrhythmic, and other cardiovascular effects on isolated guinea pig heart tissues in comparison to well-established reference drugs. According to their structures, the tested compounds are assembled into three subsets: (a) N-(quinolizidinyl-alkyl)-benzamides; (b) 2-(benzotriazol-2-yl)methyl-1-(quinolizidinyl)alkyl-benzimidazoles; (c) N-substituted cytisines. All compounds but two displayed antiarrhythmic activity that was potent for compounds , , , and (in ascending order).
View Article and Find Full Text PDFStereoselective Synthesis of Allylic Alcohols via Substrate Control on Asymmetric Lithiation.
Chemistry
January 2024
Institute of Organic Chemistry, Gottfried Wilhelm Leibniz Universität Hannover, 30167, Hannover, Germany.
Allylic alcohols are a privileged motif in natural product synthesis and new methods that access them in a stereoselective fashion are highly sought after. Toward this goal, we found that chiral acetonide-protected polyketide fragments performing the Hoppe-Matteson-Aggarwal rearrangement in the absence of sparteine with high yields and diastereoselectivities rendering this protocol a highly valuable alternative to the Nozaki-Hiyama-Takai-Kishi reaction. Various stereodyads and -triads were investigated to determine their substrate induction.
View Article and Find Full Text PDFCholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca antagonism and maintaining mitochondrial function.
J Ethnopharmacol
January 2024
Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Academy of Chinese Medicine Science, Chengdu, 610000, China. Electronic address:
Ethnopharmacological Relevance: Musk, a traditional Chinese medicine, is broadly used in inducing resuscitation and refreshing the mind, activating blood and alleviating pain. It is commonly used for the treatment of ischemic stroke, and muscone is its core medicinal component.
Aim Of The Study: The aim of this study was to explore whether muscone ameliorates neuronal damage through cholinergic signaling of muscarinic receptors.
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