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Background/aims: Certain sociodemographic groups are routinely underrepresented in clinical trials, limiting generalisability. Here, we describe the extent to which enriched enrolment approaches yielded a diverse trial population enriched for older age in a randomised controlled trial of a blood-based multi-cancer early detection test (NCT05611632).
Methods: Participants aged 50-77 years were recruited from eight Cancer Alliance regions in England.
Influence of Microstructure on Music Properties of SWP-B Music Steel Wire Under Different Annealing Treatments.
Materials (Basel)
January 2025
Joint R&D Center for Metallic Materials, Metallic Wire and Metallic Card Clothing, Xi'an 710021, China.
The mechanical properties of music wire are contingent upon its microstructure, which in turn influences its applications in music. Chinese stringed instruments necessitate exacting standards for comprehensive performance indexes, particularly with regard to the strength, resilience, and rigidity of the musical steel wires, which differ from the Western approach to musical wire. In this study, SWP-B music wire was selected for investigation through metal heat treatment, which was employed to regulate its microstructure characteristics.
View Article and Find Full Text PDFAlveolar Rhabdomyosarcoma of Nasopharynx and Paranasal Sinuses in Children Diagnosis and Treatment-Review of the Literature and Case Report.
Medicina (Kaunas)
January 2025
ENT Clinic Department, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Universitatii Street 16, 700115 Iasi, Romania.
Alveolar rhabdomyosarcoma (aRMS) is a rare pediatric malignant tumor with a poor prognosis, particularly when located in the rhinopharynx and sphenoidal floor, which complicates diagnosis and increases the risk of misclassification as benign growths. The specific genotype of aRMS is associated with a worse clinical outcome. In young children, especially those aged 4 to 12 years, rhinopharyngeal masses are often attributed to chronic adenoiditis; however, other benign (e.
View Article and Find Full Text PDFEnhancing the physical and oxidative stability of hempseed protein emulsion via comparative enzymolysis with different proteases: Interfacial properties of the adsorption layer.
Food Res Int
February 2025
College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225127, China. Electronic address:
Effects of enzymolysis by seven proteases (Alcalase, Bromelain, Flavourzyme, Papain, Pepsin, Protamex, and Trypsin) with distinct cleavage specificities on the emulsification performance of hempseed protein (HPI) and its correlation with the structural and interfacial characteristics were explored in this study. Upon enzymolysis, a remarkable decrease in α-helix and β-turn was observed in resultant hydrolysates (HPH), accompanied by a rise in β-sheet and random coil, notably by Alcalase, Bromelain, Papain, and Trypsin. Overall, proteolysis led to noticeable reductions in surface hydrophobicity and total sulfhydryls as well as a redshift in intrinsic fluorescence, with Papain showing the most pronounced effects, possibly due to its higher hydrolysis degree (4.
View Article and Find Full Text PDFThe impact of advertising on women's self-perception: a systematic review.
Front Psychol
January 2025
Department of Curriculum and Instruction, The Education University of Hong Kong, Tai Po, Hong Kong SAR, China.
This systematic review explores the multifaceted psychological impact of advertising on women's self-perception, examining traditional advertising, femvertising, and the emerging effects of digital transformation. By synthesizing evidence from 95 peer-reviewed studies, this review examines the relationship between media portrayals of women and key psychological outcomes, including body image, self-esteem, self-objectification, and gender role attitudes. Our analysis reveals that traditional advertising, which often features idealized and stereotypical portrayals of femininity, continues to be associated with negative psychological outcomes such as increased body dissatisfaction and self-objectification.
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