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Neonatal Hypoglycemia and Neurodevelopmental Outcomes-An Updated Systematic Review and Meta-Analysis.
Life (Basel)
December 2024
Department of Neonatology, Emergency County Hospital Bihor, 410167 Oradea, Romania.
Background And Objective: The effects of neonatal hypoglycemia on the developing brain are well known, resulting in poor neurological outcomes. We aimed to perform an updated meta-analysis on neonatal hypoglycemia, the severity of hypoglycemia, and the associated neurodevelopmental outcomes from infancy to adulthood.
Methods: A systematic literature search was conducted from inception until March 2024, using the PubMed, CINAHL, Embase, and the CENTRAL databases.
Recognition of GCK Homozygote missense (His424Tyr) variant in a female patient with neonatal hyperglycemia.
J Diabetes Metab Disord
December 2024
Evidence Based Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Heterozygous mutations in the GCK gene result in mildly elevated glucose levels from birth, and the homozygous loss-of-function mutations leads to permanent neonatal diabetes. In the present study we aim to investigate the cause of diabetes in an adult female patient with unusual course of diabetes.
Case Presentation: We evaluate a female patient who previously encountered significant hyperglycemia during the infancy and subsequently experienced a relatively uneventful childhood.
Fetal biometry measurements in diabetic pregnant women and neonatal outcomes.
Obstet Gynecol Sci
November 2024
Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Article Synopsis
- * Data were analyzed from 473 mothers who delivered full-term infants, assessing fetal measurements and neonatal outcomes like ICU admission and hypoglycemia.
- * Results showed that a head-to-abdominal circumference ratio of less than 0.95 and a difference of at least 2.5 cm were significantly linked to neonatal hypoglycemia, particularly in the PGDM group, with no significant findings in normal pregnancies.
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