Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma.
J Transl Med
November 2023
Experimental and Clinical Pharmacology, Centro Di Riferimento Oncologico (CRO) Di Aviano IRCCS, 33081, Aviano, Italy.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a very low survival rate at 5 years. The use of chemotherapeutic agents results in only modest prolongation of survival and is generally associated with the occurrence of toxicity effects. Antibody-based immunotherapy has been proposed for the treatment of PDAC, but its efficacy has so far proved limited.
View Article and Find Full Text PDFReduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women.
BMC Med
August 2021
Burnet Institute, 85 Commercial Road, Melbourne, Victoria, 3004, Australia.
Background: The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P. falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy outcomes. Parasite accumulation is primarily mediated by P.
View Article and Find Full Text PDFComplement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.
Invest Ophthalmol Vis Sci
June 2017
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States.
Purpose: Complement activation is implicated in the pathogenesis of age-related macular degeneration (AMD). Apolipoprotein E (ApoE) and complement activation products such as membrane attack complex (MAC) are present in eyes of individuals with AMD. Herein, we investigated the effect of complement activation on induction of ApoE accumulation in human retinal pigment epithelial (RPE) cells.
View Article and Find Full Text PDFThe human thymus perivascular space is a functional niche for viral-specific plasma cells.
Sci Immunol
December 2016
Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
The human thymus is susceptible to viral infections that can severely alter thymopoiesis and compromise the mechanisms of acquired tolerance to self-antigens. In humans, plasma cells residing primarily in the bone marrow confer long-lasting protection to common viruses by secreting antigen-specific antibodies. Since the thymus also houses B cells, we examined the phenotypic complexity of these thymic resident cells and their possible protective role against viral infections.
View Article and Find Full Text PDFDesensitization Strategies Pre- and Post-Cardiac Transplantation.
Curr Treat Options Cardiovasc Med
February 2016
Cedars-Sinai Heart Institute, 127 S. San Vicente Blvd, Los Angeles, CA, 90048, USA.
Panel reactive antibody (PRA) testing has become standard in the evaluation of patients prior to cardiac transplant. Sensitizing events such as blood transfusions, which result in the accumulation of pre-transplant antibodies, should be avoided as clinically feasible. Desensitization therapy might be considered in sensitized patients with cPRA > 50 % although distinct cutoff PRA values for initiating therapy pre-transplant are patient and transplant program dependent.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!