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Cardio- and Vasoprotective Effects of Quinacrine in an In Vivo Rat Model of Myocardial Ischemia/Reperfusion Injury.
Bull Exp Biol Med
June 2024
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
This study aimed to investigate the cardioprotective effect of quinacrine in an in vivo model of myocardial ischemia/reperfusion injury. A 30-min regional myocardial ischemia followed by a 2-h reperfusion was modeled in anesthetized Wistar rats. Starting at the last minute of ischemia and during the first 9 min of reperfusion the rats in the control (n=8) and experimental (n=9) groups were injected with 0.
View Article and Find Full Text PDFSmall Molecule IITR08367 Potentiates Antibacterial Efficacy of Fosfomycin against by Efflux Pump Inhibition.
ACS Infect Dis
May 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology, Roorkee, Uttarakhand 247 667, India.
Fosfomycin is a broad-spectrum single-dose therapy approved for treating lower urinary tract infections. , one of the five major UTI-causing pathogens, is intrinsically resistant to fosfomycin. Reduced uptake and active efflux are major reasons for this intrinsic resistance.
View Article and Find Full Text PDFQuantification of Intracellular ATP Content in Ex Vivo GC B Cells.
Methods Mol Biol
June 2023
Centro de Biología Molecular Severo Ochoa, Consejo Superior de investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain.
The study of immunometabolism is an important and emerging field in immunology. B-cell activation upon antigen recognition induces profound metabolic changes in the cell, leading to an increase in ATP production to sustain cell proliferation and differentiation. Current methods available to determine the amount of ATP are time-consuming, require extensive sample processing, and need a large amount of starting material.
View Article and Find Full Text PDFKetotifen is a microglial stabilizer by inhibiting secretory vesicle acidification.
Life Sci
April 2023
Dpto. de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Spain. Electronic address:
Aims: Microglia survey the brain environment by sensing alarm signals to provide the first line of defense against injury or infection after which they acquire an activated phenotype, but they also respond to chemical signals sent from brain mast cells, sentinels of the immune system, when these are degranulated in response to noxious agents. Nevertheless, excessive microglia activation damages the surrounding healthy neural tissue causing progressive loss of neurons and inducing chronic inflammation. Thus, it would be of intense interest the development and application of agents which prevent mast cell mediator release and inhibit the actions of such mediators once released on microglia.
View Article and Find Full Text PDFMultimodal Investigation into the Interaction of Quinacrine with Microcavity-Supported Lipid Bilayers.
Langmuir
May 2022
School of Chemical Science and National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland.
Quinacrine is a versatile drug that is widely recognized for its antimalarial action through its inhibition of the phospholipase enzyme. It also has antianthelmintic and antiprotozoan activities and is a strong DNA binder that may be used to combat multidrug resistance in cancer. Despite extensive cell-based studies, a detailed understanding of quinacrine's influence on the cell membrane, including permeability, binding, and rearrangement at the molecular level, is lacking.
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