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The Synergistic Mechanism of Alkaloids on Melanoma Treatment via a Multi-Strategy Insight.
Molecules
November 2024
Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China.
Melanoma represents a formidable challenge in dermatological oncology due to its resistance to conventional treatments. The Celandine Alkali Injection Formula (CAIF) offers benefits on clinical internal medicine treatments, within which chelidonine and tetrandrine are recognized as potential quality markers. However, their synergistic mechanisms facilitating their anti-melanoma action remain unveiled.
View Article and Find Full Text PDFChelerythrine inhibits NR2B NMDA receptor independent of PKC activity.
Biochem Biophys Res Commun
December 2024
Department of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, Hebei Medical University, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei, 050017, China. Electronic address:
Article Synopsis
- - N-methyl-d-aspartate receptors (NMDARs) are key players in excitatory neurotransmission in the central nervous system and are linked to several neurological disorders, making them a target for potential therapies.
- - The study investigates the effects of chelerythrine (CHE), an alkaloid with various biological activities, on NMDAR function, revealing that CHE suppresses NMDA-induced currents in neurons and facilitates desensitization of GluN2B NMDARs.
- - The inhibitory action of CHE on GluN2B NMDARs is independent of protein kinase C activity and is influenced by pH, with specific interactions identified at the receptor's M3 α-helical
[Scurvy-A now forgotten previously widespread disease].
Wien Med Wochenschr
October 2024
Medizinische Universität Wien, Martinstraße 7, 3400, Klosterneuburg, Österreich.
From the sea voyages of the fifteenth century often lasting for years with provisions only of fish, salted meat and biscuits reports came of fatal health alterations of the seamen which were characterized by prostration, loss of teeth and bad breath.Reports on comparable endemic illnesses soon came from the Netherlands, North Germany, the Baltic area, France, Lorraine, Geneva, Bohemia, Moravia, Silesia, Swabia and Russia: the so-called land scurvy. The first medical specification was found in a letter from 1541 by Johann Echt to colleges in the area of Lower Germany, which was published four times.
View Article and Find Full Text PDFBioactive Compounds Produced by Endophytic Bacteria and Their Plant Hosts-An Insight into the World of Chosen Herbaceous Ruderal Plants in Central Europe.
Molecules
September 2024
Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 2/22, 90-537 Lodz, Poland.
The natural environment has been significantly impacted by human activity, urbanization, and industrialization, leading to changes in living organisms and their adaptation to harsh conditions. Species, including plants, adapt to these changes by creating mechanisms and modifications that allow them to survive in harsh environments. Also, endophytes, microorganisms that live inside plants, can support plant growth and defense mechanisms in these conditions by synthesizing antimicrobial secondary metabolites.
View Article and Find Full Text PDFEnhancing Wound Healing: A Comprehensive Review of Sericin and L. as Potential Dressings.
Materials (Basel)
August 2024
Centro de Investigação da Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Wound healing, a complex physiological process orchestrating intricate cellular and molecular events, seeks to restore tissue integrity. The burgeoning interest in leveraging the therapeutic potential of natural substances for advanced wound dressings is a recent phenomenon. Notably, Sericin, a silk-derived protein, and L.
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