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Biomarkers.
Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Moderate alcohol use may be associated with brain and cognitive benefits compared to heavy alcohol use. However, results have varied. We hypothesized that the relationship between alcohol use and cognition is mediated by neurodegenerative and cerebrovascular measures in a diverse middle-aged sample of non-alcohol dependent community-dwelling adults in Northern Manhattan.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of Pennsylvania, School of Nursing, Philadelphia, PA, USA.
Background: The human brain is organized in dense and distinct intrinsic networks that are topographically arranged and mediate particular cognitive functions. The characteristic of intrinsic network organization that supports this functional specialization of cognitive domains is known as modular segregation. Neurodegeneration is associated with changes in brain network organization that contribute to cognitive decline among healthy older adults but network segregation has rarely been studied in behavioral variant frontotemporal dementia (bvFTD).
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Characterizing stress can inform our understanding of direct and indirect pathways impacting mental and physical health outcomes, including age-related cognitive decline. Chronic stress has been strongly associated with increased risk for cognitive decline, and hair cortisol concentration (HCC) has emerged as a viable neuroendocrine biomarker for its quantification. Cognitive appraisal of stress (CAS) provides key insight into the cognitive framework for responding to a given stressor.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Moderate alcohol use may be associated with brain and cognitive benefits compared to heavy alcohol use. However, results have varied. We hypothesized that the relationship between alcohol use and cognition is mediated by neurodegenerative and cerebrovascular measures in a diverse middle-aged sample of non-alcohol dependent community-dwelling adults in Northern Manhattan.
View Article and Find Full Text PDFd-p Hybridization Induced Open-Shell Planar Four-Membered Transition Metal Carbide Clusters with Double Möbius Aromaticity.
J Phys Chem A
January 2025
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China.
Aromaticity is one of the most classical concepts in the field of modern chemistry and has been employed to explain and design substances with special stability. Although the knowledge about Hückel's and Baird's rules has been well established, the understanding of Möbius aromaticity remains extremely limited. In this letter, by employing density functional theory (DFT) calculations, we demonstrated that the four-membered VIB transition metal (TM) carbide clusters possess a highly stable open-shell planar tetrameric structure and exhibit double Möbius aromaticity, which was evidenced by analyzing multiple aromaticity criteria, including the electronic, magnetic, and energetic indicators.
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