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Microbial Lineages in Sarcoidosis. A Metagenomic Analysis Tailored for Low-Microbial Content Samples.
Am J Respir Crit Care Med
January 2018
3 Department of Medicine, and.
Rationale: The etiology of sarcoidosis is unknown, but microbial agents are suspected as triggers.
Objectives: We sought to identify bacterial, fungal, or viral lineages in specimens from patients with sarcoidosis enriched relative to control subjects using metagenomic DNA sequencing. Because DNA from environmental contamination contributes disproportionately to samples with low authentic microbial content, we developed improved methods for filtering environmental contamination.
Seasonality of the onset of symptoms, tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis.
Respirology
July 2007
Division of Lung Diseases, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istnbul, Turkey.
Background And Objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim test responses.
Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed.
Pathology of sarcoidosis.
Semin Respir Crit Care Med
February 2007
Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn, New York , USA.
The role of pathology in the diagnosis of sarcoidosis is identification of granulomas in tissue specimens and performance of studies to exclude known causes of granulomatous inflammation. The granulomas of sarcoidosis are nonspecific lesions that, by themselves and in the absence of an identifiable etiologic agent, are not diagnostic of sarcoidosis or any other specific disease. Among the diseases to be excluded are mycobacterial, fungal, and parasitic infections, chronic beryllium disease and other pneumoconiosis, hypersensitivity pneumonitis, and Wegener's granulomatosis.
View Article and Find Full Text PDF[Diagnostic criteria of neurosarcoidosis].
No To Shinkei
June 2006
Department of Neurology, Kyorin University.
We have collaborated with Japanese Sarcoidosis Society and Japanese Society of Respiratory Disease to provide a new diagnostic criteria of neurosarcoidosis. At least two of six examinations are important. These include bilateral hilar lymphadenopathy, abnormal uptake of 67Ga scintigraphy, broncho alveolar lavage fluid examination, elevated serum ACE, negative tuberculin reaction, and elevated serum or urinary calcium level.
View Article and Find Full Text PDF[Diagnostic criteria of neurosarcoidosis].
Rinsho Shinkeigaku
November 2005
Dpt Neurology, Kyorin University.
We have collaborated with Japanese Sarcoidosis Society and Japanese Society of Respiratory diseases to make a new diagnostic criteria of neurosarcoidosis. (definite) Having positive clinical findings which suggest a neurosarcoidosis. Pathology proven case.
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