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Background: The burden of hospital-acquired infections (HAIs) equates to 3.5 million cases, resulting in more than 90 000 deaths and 2.5 million disability-adjusted life years (DALYs) across Europe.
View Article and Find Full Text PDFHarnessing the AI/ML in Drug and Biological Products Discovery and Development: The Regulatory Perspective.
Pharmaceuticals (Basel)
January 2025
College of Pharmacy, University of Illinois, Chicago, IL 60612, USA.
Artificial Intelligence (AI) has the disruptive potential to transform patients' lives via innovations in pharmaceutical sciences, drug development, clinical trials, and manufacturing. However, it presents significant challenges, ethical concerns, and risks across sectors and societies. AI's rapid advancement has revealed regulatory gaps as existing public policies struggle to keep pace with the challenges posed by these emerging technologies.
View Article and Find Full Text PDFSP-YOLO: A Real-Time and Efficient Multi-Scale Model for Pest Detection in Sugar Beet Fields.
Insects
January 2025
College of Life Science and Technology, Xinjiang University, Urumqi 830017, China.
Beet crops are highly vulnerable to pest infestations throughout their growth cycle, which significantly affects crop development and yield. Timely and accurate pest identification is crucial for implementing effective control measures. Current pest detection tasks face two primary challenges: first, pests frequently blend into their environment due to similar colors, making it difficult to capture distinguishing features in the field; second, pest images exhibit scale variations under different viewing angles, lighting conditions, and distances, which complicates the detection process.
View Article and Find Full Text PDFNeuroinflammation at the Dorsolateral Inferior Medulla: A Possible Central Nervous System Localization for POTS and Long COVID.
Biomedicines
January 2025
Department of Neurology, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA.
Both postural orthostatic tachycardia syndrome (POTS) and Long COVID are currently viewed as heterogeneous disorders with complex, multi-factorial and multi-systemic pathophysiology. POTS, one of the most common autonomic disorders, is a frequent sequela of SARS-CoV-2 infection. Both POTS and autonomic dysfunction, in general, are major pathophysiologic mechanisms of Long COVID.
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