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Nicotinamide adenine dinucleotide supplementation fails to enhance anesthetic recovery in rodents.
Sci Rep
January 2025
Department of Anesthesiology, Perioperative, and Pain Medicine, School of Medicine, Stanford University, Stanford, USA.
Nicotinamide Adenine Dinucleotide (NAD) is implicated in bioenergetics, DNA repair, and senescence. Depletion of NAD is associated with aging and neurodegenerative disease, prompting a growing interest in NAD supplementation. With rising over-the-counter use of NAD, understanding their impact on anesthetic recovery becomes essential.
View Article and Find Full Text PDFNear-infrared fluorogenic RNA for in vivo imaging and sensing.
Nat Commun
January 2025
Interdisciplinary Science Center, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.
Fluorogenic RNA aptamers have various applications, including use as fluorescent tags for imaging RNA trafficking and as indicators of RNA-based sensors that exhibit fluorescence upon binding small-molecule fluorophores in living cells. Current fluorogenic RNA:fluorophore complexes typically emit visible fluorescence. However, it is challenging to develop fluorogenic RNA with near-infrared (NIR) fluorescence for in vivo imaging and sensing studies.
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Alzheimers Dement
December 2024
Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.
Background: Cerebrospinal fluid (CSF) proteomics allows for characterization of multiple disease-related biological processes in vivo. These processes likely occur along temporal cascades mirroring disease evolution. This study describes interindividual variation in these cascades, in the context of Alzheimer's disease.
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Alzheimers Dement
December 2024
Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada.
Background: Apathy in patients with Alzheimer's disease (AD) is associated with significant morbidity. We examined whether interactions between genetic variants related to neurotransmitter systems and regional brain atrophy are associated with apathy in patients with mild cognitive impairment (MCI) and AD.
Method: For 1162 participants in the Alzheimer's Disease Neuroimaging Initiative, including those with AD, MCI and cognitively normal individuals, a partial least squares correspondence analysis (PLS-CA) modeled interactions between single nucleotide polymorphisms (SNPs), structural whole-brain imaging variables, and apathy.
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Alzheimers Dement
December 2024
The William H. Annesley, Jr, EyeBrain Center, Farber Neuroscience Institute at Thomas Jefferson University, Philadelphia, PA, USA.
Background: FLIO a novel in vivo reproducible, non-invasive imaging technology, measures fluorescence lifetime decay in two spectral channels for short-lived retinal chromophores in two domains: Channel 1 emission wavelength 498-560 nm corresponding to NADH and FAD/ATP function and Channel 2, 560-720 nm wavelength corresponding to lipofuscin/lysosomal function. These data reflect the retinal mitochondrial molecular environment. Mitochondrial dysfunction has been recently explored as a cause of decreased synaptic function and cognitive decline in AD.
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