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Case report: Plasma exchange treatment in a patient with severe tetanus.
Transfus Apher Sci
November 2024
Department of Emergency, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; Department of Thyroid Breast Surgery, Shantou Central Hospital, Shantou, Guangdong, China. Electronic address:
Article Synopsis
- - Tetanus, caused by Clostridium tetani, leads to severe symptoms like muscle spasms and can be life-threatening due to its toxin, but plasma exchange is rarely used in treatment due to its complexity and cost.
- - A 57-year-old man with tetanus symptoms, such as lockjaw and neck stiffness, experienced rapid decline and cardiac arrest, but after resuscitation and ICU care, he received plasma exchange treatment.
- - The patient's partial recovery highlights plasma exchange's potential to remove harmful substances from the body, suggesting it could be a new treatment option for severe tetanus cases despite its uncommon application.
Routine immunization against and type B and antibiotic consumption in India: a dynamic modeling analysis.
Lancet Reg Health Southeast Asia
December 2024
One Health Trust, Washington, DC, USA.
Background: Childhood vaccinations can reduce disease burden and associated antibiotic use, in turn reducing the risk of antimicrobial resistance (AMR). We retrospectively estimated the population-level reductions in antibiotic use in India following the introduction of vaccines against and type B in the national immunization program for children in the mid-2010s and projected future gains to 2028 if vaccination coverage were to be increased.
Methods: Using IndiaSim, a dynamic agent-based microsimulation model (ABM) for India, we simulated the spread of and type B (Hib) among children to estimate reductions in antibiotic use under the scenarios of: (i) pneumococcal and Hib vaccine coverage levels equivalent to the national coverage of pentavalent diphtheria-pertussis-tetanus third dose (DPT3) compared to a baseline of no vaccination, and (ii) near-universal (90%) coverage of the vaccines compared to pre-COVID national DPT3-level coverage.
The compatibility of mandatory vaccinations with human rights has become a very current issue with the COVID-19 pandemic and the Vavřička ruling by the European Court of Human Rights. This ruling has faced criticism for not conducting examinations related to disease and vaccines based on direct scientific evidence. In this analysis, an assessment will be made based on direct scientific evidence about tetanus and its vaccine.
View Article and Find Full Text PDFA literature review and evidence-based evaluation of the Dutch national immunisation schedule yield possibilities for improvements.
Vaccine X
October 2024
Center for Infectious Disease Control (CIb), National Institute for Public Health and the Environment (RIVM), The Netherlands.
National Immunisation Programmes (NIPs) develop historically. Its performance (disease incidences, vaccination coverage) is monitored. Reviewing the schedule as a whole could inform on further optimisation of the programme, i.
View Article and Find Full Text PDFThiamine: An indispensable regulator of paediatric neuro-cardiovascular health and diseases.
Eur J Pediatr
November 2024
Department of Paediatrics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576104.
Unlabelled: The sustainable developmental goals emphasize good health, reduction in preventable neonatal and under-five mortalities, and attaining zero hunger. However, South Asian countries report a higher incidence of neonatal and under-five mortalities when compared to the Western world, many of which are attributed to maternal and perinatal micronutrient deficiencies. Isolated nutrient deficiency in the absence of calorie deficit poses a diagnostic challenge since such deficiencies present with acute multisystemic and enigmatic manifestations.
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