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Characterization of a chitinase from Trichinella spiralis and its immunomodulatory effects on allergic airway inflammation in mice.
Parasit Vectors
January 2025
School of Basic Medicine Science, Fujian Province, Putian University, Key Laboratory of Translational Tumor Medicine in , Putian City, 351100, Fujian Province, China.
Background: A fundamental tenet of the hygiene theory is the inverse association between helminth infections and the emergence of immune-mediated diseases. Research has been done to clarify the processes by which helminth-derived molecules can inhibit immunological disorders. This study aimed to evaluate the ability of Trichinella spiralis chitinase (Ts-chit) to ameliorate the symptoms of allergic airway inflammation.
View Article and Find Full Text PDFIn vivo study of nano chitosan beads-based ELISA versus traditional sandwich ELISA for the early diagnosis of trichinosis.
Exp Parasitol
January 2025
Medical Parasitology, Faculty of Medicine, Beni-Suef University, Egypt. Electronic address:
Human trichinosis is a serious foodborne parasitic zoonosis. Diagnosing human trichinosis is usually difficult due to the nonspecific clinical picture and the limited effectiveness of serological tests in acute infections. While ELISA can detect circulating Trichinella antigens, aiding in early diagnosis, its sensitivity may be low.
View Article and Find Full Text PDFThe gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis.
PLoS Negl Trop Dis
November 2024
Department of Pathogen Biology, Medical College of Zhengzhou University, Zhengzhou, Henan, China.
Background: Inflammatory bowel disease (IBD) increases the risk of colorectal cancer, and it has the potential to diminish the quality of life. Clinical and experimental evidence demonstrate protective aspects of parasitic helminth infection against IBD. However, studies on the inhibition of inflammation by helminth infection have overlooked a key determinant of health: the gut microbiota.
View Article and Find Full Text PDFInterleukin 17 producing T cell responses in human chronic trichinellosis-insight from a case study.
Cytokine
December 2024
Department of Translational Research, N.T.M.S., Università di Pisa, Pisa, Italy. Electronic address:
Introduction: We studied the cellular immune response in a patient infected since 10 months (along with other 51 people) during a trichinellosis outbreak caused by Trichinella spp.
Methods: A 46 years old female resulted serologically positive for trichinellosis. We isolated peripheral blood mononuclear cells (PBMCs) and incubated them with excretory/secretory antigens (ESA) of Trichinella spiralis (T1) or Trichinella pseudospiralis (T4) to produce antigen specific T cell lines and clones, analysed for the phenotype (T helper or cytotoxic cells), for their T4 or T1 antigens specificity and for their cytokine profile (IFNγ, IL-17A, IL-4) by flow cytometry, thymidine incorporation assay and ELISpot.
Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis.
BMC Vet Res
September 2024
Department of Parasitology, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.
Article Synopsis
- The study explored the effects of pumpkin seed oil on mice infected with the parasite Trichinella spiralis, focusing on its potential to reduce inflammation and parasite levels.
- Mice were divided into five groups and treated with either pumpkin seed oil, albendazole, or served as controls, revealing that pumpkin seed oil significantly lowered parasite numbers and reduced inflammation in the intestines.
- The results indicate that pumpkin seed oil not only decreases parasite burden but also lowers MMP-9 levels, highlighting its promise as an anti-inflammatory and antiparasitic treatment.
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