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Exploring melatonin's signalling pathways in the protection against age-related skin deterioration.
Pharmacol Rep
January 2025
Razi Drug Research Centre, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Melatonin, renowned for regulating sleep-wake cycles, also exhibits notable anti-aging properties for the skin. Synthesized in the pineal gland and various tissues including the skin, melatonin's efficacy arises from its capacity to combat oxidative stress and shield the skin from ultraviolet (UV)-induced damage. Moreover, it curbs melanin production, thereby potentially ameliorating hyperpigmentation.
View Article and Find Full Text PDFGenetic evidence for functions of Chloroplast CA in Pyropia yezoensis: decreased CCM but increased starch accumulation.
Adv Biotechnol (Singap)
April 2024
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
In response to the changing intertidal environment, intertidal macroalgae have evolved complicated Ci utilization mechanisms. However, our knowledge regarding the CO concentrating mechanism (CCM) of macroalgae is limited. Carbonic anhydrase (CA), a key component of CCM, plays essential roles in many physiological reactions in various organisms.
View Article and Find Full Text PDFIncreased default mode network activation in depression and social anxiety during upward social comparison.
Soc Cogn Affect Neurosci
January 2025
Center for Basic Research in Psychology (CIBPsi), Facultad de Psicología, Universidad de la República, Montevideo, Uruguay.
Social comparisons are a core feature of human life. Theories posit that social comparisons play a critical role in depression and social anxiety triggering negative evaluations about the self, as well as negative emotions. We investigated the neural basis of social comparisons in participants with depression and/or social anxiety (MD-SA, n=56) and healthy controls (n=47) using functional magnetic resonance imaging (fMRI).
View Article and Find Full Text PDFCathepsin B Activatable Fluorescent Probe for Antitumor Efficiency Feedback: Attempt To Detect Certain Apoptotic Cells.
Anal Chem
January 2025
Key Laboratory of Organosilicon Chemistry and Materials Technology of the Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, P. R. China.
As many treatments kill tumor cells by inducing apoptosis, fluorescent probes that can detect apoptosis are crucial for effective feedback regarding tumor therapy outcomes (in particular, activatable probes for better imaging). Cathepsins are enzymes that are released from lysosomes into the cytoplasm during lysosomal membrane permeabilization-induced apoptosis of many tumor cells, making them potential biomarkers of apoptotic cells. Despite their potential, to the best of our knowledge, no cathepsin-activatable fluorescent probes have been reported for this purpose.
View Article and Find Full Text PDFPublic and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial.
Health Technol Assess
January 2025
School of Medicine, Keele University, Keele, Staffordshire, UK.
Background: For people receiving haemodialysis, a balance has to be struck between removing sufficient but not too much fluid during a treatment session and maintaining any remaining kidney function they might have. In the BISTRO trial, this study sought to establish if getting the balance right might be improved by the additional use of bioimpedance, a device that measures body fluid composition to help decide how much fluid to remove during dialysis. Designing and executing this trial, which incorporated complex and repeated trial procedures that would be dependent on participant engagement, presented challenges that demanded effective public and patient involvement.
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