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Purpose: The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select the best therapy, predictive biomarkers are necessary.
View Article and Find Full Text PDFIdentification of Novel Basil Downy Mildew Resistance Genes Using Comparative Transcriptomics.
Phytopathology
March 2025
University of Massachusetts Amherst, Biochemistry and Molecular Biology, Amherst, Massachusetts, United States;
Sweet basil ( L.) production is threatened by the oomycete pathogen , causing basil downy mildew (BDM). BDM-resistant cultivar 'Mrihani' (MRI) was identified in a germplasm screen, and bred with BDM-susceptible 'Newton' (SB22) to produce resistant cultivars, but the molecular mechanisms conferring resistance in MRI and the progeny remained unknown.
View Article and Find Full Text PDFChildcare and Meal Provision: A Systematic Literature Review.
Nutr Rev
March 2025
Mathematica, Washington, DC 20002, United States.
Background: The Child and Adult Care Food Program (CACFP) provides reimbursement for meals and snacks that meet nutrition standards served to children enrolled at participating childcare centers and family daycare homes. This program plays an important role in the health and well-being of children and families. Despite the benefits, many eligible childcare providers do not participate in CACFP.
View Article and Find Full Text PDFSoluble Factors and Mechanisms Regulated by Sialylated IgG Signaling.
Immunol Rev
March 2025
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Inflammation is a complex biological response that can be both induced and actively suppressed by IgG-Fc gamma receptor (FcγR) interactions. This review explores the role of IgG sialylation in reducing or blocking inflammatory responses. We first revisit foundational studies that established the anti-inflammatory properties of sialylated IgG1 Fc.
View Article and Find Full Text PDFThe insertion of the inverted repeat of an insertion sequence (IS) element from changes the host range and stability of pGK12, a shuttle vector for lactic acid bacteria.
Appl Environ Microbiol
March 2025
Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Unlabelled: Insertion sequences (ISs) are key components of most bacterial genomes and play a crucial role in bacterial mutagenesis. In this study, we observed the insertion of an IS element, ISLrh, from the M1 genome into plasmid pGK12, resulting in the generation of a new plasmid, pTRK829. This insertion enabled pTRK829 to replicate in hosts previously incompatible with pGK12, including M1, GG (LGG), ATCC 393, and ATCC 25598.
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