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Navigating Challenges in Adult Airway Foreign Body Extraction: Retrospective Insights From Flexible Bronchoscopy.
Cureus
December 2024
Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Background Airway foreign body aspiration is an emergency predominantly observed in children and the elderly. However, it also occurs in adults, presenting with a variety of symptoms. Both rigid and flexible bronchoscopies are employed for foreign body retrieval.
View Article and Find Full Text PDFReview of cancer cell volatile organic compounds: their metabolism and evolution.
Front Mol Biosci
January 2025
Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria.
Cancer is ranked as the top cause of premature mortality. Volatile organic compounds (VOCs) are produced from catalytic peroxidation by reactive oxygen species (ROS) and have become a highly attractive non-invasive cancer screening approach. For future clinical applications, however, the correlation between cancer hallmarks and cancer-specific VOCs requires further study.
View Article and Find Full Text PDFStrategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer.
Mater Today Bio
February 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Fibroblast activating protein (FAP) is up-regulated in cancer-associated fibroblasts (CAFs) of more than 90 % of tumor microenvironment and also highly expressed on the surface of multiple tumor cells like glioblastoma, which can be used as a specific target for tumor diagnosis and treatment. At present, small-molecule radiotracer targeting FAP with high specificity exhibit limited functionality, which hinders the integration of theranostics as well as multifunctionality. In this work, we have engineered a multifunctional nanoplatform utilizing organic melanin nanoparticles that specifically targets FAP, facilitating both multimodal imaging and synergistic therapeutic applications.
View Article and Find Full Text PDFDoes Nonsteroidal Anti-inflammatory Drug Use Modify All-Cause and Cause-Specific Mortality Associated with PM and Its Components? A Nationally Representative Cohort Study (2007-2017).
Environ Health (Wash)
January 2025
Institute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
Several studies reported that nonsteroidal anti-inflammatory drug (NSAID) use could alleviate subclinical effects of short-term exposure to fine particulate matter (PM). However, whether chronic NSAID use could mitigate the long-term effects of PM and its components on population mortality has been unknown. Based on a national representative survey of 47,086 adults (2007-2010) with follow-up information on the primary cause of death (until 2017), we investigated the long-term associations of PM and its major components, including black carbon (BC), ammonium (NH ), nitrate (NO ), organic matter (OM), and sulfate (SO ), with all-cause and cause-specific mortality using the Cox proportional hazards model.
View Article and Find Full Text PDFDefect-Engineered Luminescent Nanozyme with Enhanced Phosphohydrolase Activity for Degradation and Dual-Mode Detection of Paraoxon.
Small
January 2025
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
The excessive use of organophosphorus pesticides poses a substantial threat to both human health and the environment. Consequently, there is an urgent need for new methods that can quickly degrade and sensitively detect these compounds. A versatile nanozyme based on the biomimetic principle is an effective strategy to solve this problem.
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