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Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro.
Haematologica
July 2012
Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering. Technion. Technion City, Haifa, Israel.
Background: The lifespan of red blood cells is terminated when macrophages remove senescent red blood cells by erythrophagocytosis. This puts macrophages at the center of systemic iron recycling in addition to their functions in tissue remodeling and innate immunity. Thus far, erythrophagocytosis has been studied by evaluating phagocytosis of erythrocytes that were damaged to mimic senescence.
View Article and Find Full Text PDFErythropoietin improves cardiac contractility in post-hypoxic mice.
Br J Haematol
April 2003
Pharmacology Unit, zSchool of Dentistry, University of Buenos Aires, Marcelo T. de Alvear 2142-4o"B", 1122AAH, Buenos Aires, Argentina.
Mice myocardia, in which plasma erythropoietin (EPO) concentrations were modified in response to different experimental conditions, were studied to evaluate contractility (dF/dt). CF1 mice were randomly separated into four main groups: group I, normocythaemic normoxic; group II-a, normocythaemic intermittently exposed to hypobaria for 72 h; group II-b, normocythaemic intermittently exposed to hypobaria for 3 weeks; group III, hypertransfused polycythaemic exposed to 72 h hypobaria; and group IV, hypertransfused polycythaemic maintained in normobaric air. Plasma EPO, contractile studies and binding assays were performed.
View Article and Find Full Text PDFPhysiology of erythropoietin during mammalian development.
Acta Paediatr Suppl
March 2003
Department of Pediatrics, Ullevaal University Hospital, Oslo, Norway.
Unlabelled: Growth is a fundamental process of mammalian development. Several observations regarding regulation of erythropoiesis during growth are not easily explained by the hypoxia-erythropoietin (Epo) concept. This review focuses primarily on this aspect of the physiology of Epo.
View Article and Find Full Text PDFICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture.
Blood
February 2001
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
ICL670A (formerly CGP 72 670) or 4-[3,5-bis-(hydroxyphenyl)-1,2,4-triazol-1-yl]- benzoic acid is a tridentate iron-selective synthetic chelator of the bis-hydroxyphenyl-triazole class of compounds. The present studies used selective radioiron probes of hepatocellular and reticuloendothelial (RE) iron stores in hypertransfused rats and iron-loaded heart cells to define the source of iron chelated in vivo by ICL670A and its mode of excretion, to examine its ability to remove iron directly from iron-loaded myocardial cells, and to examine its ability to interact with other chelators through a possible additive or synergistic effect. Results indicate that ICL670A given orally is 4 to 5 times more effective than parenteral deferoxamine (DFO) in promoting the excretion of chelatable iron from hepatocellular iron stores.
View Article and Find Full Text PDFPharmacokinetic properties and in-vivo biological activity of recombinant human erythropoietin encapsulated in red blood cells.
Cytokine
January 1997
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Madrid, Spain.
The in-vivo survival of 51Cr-labelled murine red blood cells (RBCs) loaded with recombinant human erythropoietin (rhEpo-RBCs) was slightly lower than that of normal RBCs. Intravenous administration to normal mice of the encapsulated rhEpo shows the pharmacokinetic bicompartmental profile typical of the free rhEpo. Distribution and elimination half-life values for the RBC-entrapped rhEpo were no longer than those for the free protein.
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