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Interspecific evolutionary relationships of alpha-glucuronidase in the genus Aspergillus.
Fungal Biol
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Estancia Posdoctoral Nacional-CONACyT, Posgrado en Ciencia y Tecnología de Alimentos, Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Ing J. Cardenas Valdez S/N, República, 25280, Saltillo, Coah, Mexico. Electronic address:
The increased availability and production of lignocellulosic agroindustrial wastes has originated proposals for their use as raw material to obtain biofuels (ethanol and biodiesel) or derived products. However, for biomass generated from lignocellulosic residues to be successfully degraded, in most cases it requires a physical (thermal), chemical, or enzymatic pretreatment before the application of microbial or enzymatic fermentation technologies (biocatalysis). In the context of enzymatic technologies, fungi have demonstrated to produce enzymes capable of degrading polysaccharides like cellulose, hemicelluloses and pectin.
View Article and Find Full Text PDFCloning of two splice variants of Spalax heparanase encoding for truncated proteins.
Anticancer Drugs
October 2020
Institute of Evolution, University of Haifa.
Heparanase is an endoglycosidase that degrades heparan sulfate side chains of heparan sulfate-proteoglycans. It liberates heparan sulfate-bound growth factors and thereby promotes blood vessel sprouting and angiogenesis. The subterranean blind mole rat, Spalax, is a wild mammal that lives most of its life in underground tunnels where it experiences sharp fluctuations in oxygen and carbon dioxide levels.
View Article and Find Full Text PDFGinsenoside Rc Is a New Selective UGT1A9 Inhibitor in Human Liver Microsomes and Recombinant Human UGT Isoforms.
Drug Metab Dispos
December 2019
BK21 Plus KNU Multi-Omics based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea
Ginseng is known to have inhibitory effects on UGT1A9 activity. However, little is known about the inhibitory effects of ginsenosides, the major active compounds in ginseng, on UGT1A9 activity. In vitro investigation of UGT1A9 inhibition by ginsenosides was carried out using human liver microsomes (HLMs).
View Article and Find Full Text PDFA panel of urinary biochemical markers for the noninvasive detection of kidney dysfunction in HIV-infected patients.
Pol Arch Intern Med
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Department of Toxicology, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland
Introduction: The use of antiretroviral therapy in HIV‑infected patients can lead to disturbances in kidney function. Renal dysfunction can also be caused by the direct effects of HIV on the kidneys. The assessment of renal function is needed to monitor these patients for the development of chronic kidney disease.
View Article and Find Full Text PDFSubtle Difference Generates Big Dissimilarity: Comparison of Enzymatic Activity in KL1 and KL2 Domains of Lancelet Klotho.
Mar Biotechnol (NY)
August 2019
Laboratory for Evolution and Development, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
Klotho, a putative aging suppressor, shares sequence similarity with members of the glycosidase family 1. It has been identified in several vertebrate species, but only mouse Klotho has so far been proven to exhibit β-glucuronidase activity. Thus, the argument that Klotho from animals other than mouse has glycosidase activity remains open.
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