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Investigation of TLR4 Polymorphism in Children with Vesicoureteral Reflux and Renal Scarring.
Balkan J Med Genet
December 2024
Department of Pediatric Endocrinology, S.B. Keçiören Eğitim ve Araştırma Hastanesi, Ankara, Turkey.
Vesicoureteral reflux (VUR) is an important factor in the etiology of recurrent urinary tract infections (UTIs). Permanent kidney damage may develop in children with high-grade VUR in the long term. This damage may progress with the development of scar tissue in some patients.
View Article and Find Full Text PDFVaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway.
Drug Des Devel Ther
March 2025
Department of Nephropathy, The Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People's Republic of China.
Purpose: Vaccarin is a natural flavonoid glycoside with anti-inflammatory, antioxidant and nephroprotective effects. However, the effects of vaccarin on renal fibrosis (RF) and its molecular mechanisms remain unclear. This study aimed to investigate the effects of vaccarin on RF and its molecular mechanisms.
View Article and Find Full Text PDFHealth-related quality of life after radical cystectomy for bladder cancer in elderly patients with ileal orthotopic neobladder, ureterocutaneostomy or ileal conduit: cross-sectional study using validated questionnaires.
BMC Urol
March 2025
Department of Urology, Ministry of Health, Dr Kemal Beyazıt State Hospital, Kahramanmaraş, Turkey.
Purpose: The most appropriate form of urinary diversion (UD) after radical cystectomy remains controversial. In this study, we aimed to compare the health-related quality of life questionnaire results of patients who underwent orthotopic neobladder (ONB), ureterocutaneostomy (UC) and ileal conduit (IC) diversion.
Materials: A total of 92 patients, including 42 out of 65 IC patients, 11 out of 15 ONB patients, and 39 out of 59 UC patients, completed the SF-36 and Barthel index quality of life questionnaires.
Unlabelled: Mowat-Wilson Syndrome (MWS) is a multiple congenital anomaly syndrome caused by mutations in the which plays a critical role in cell fate determination and differentiation during development. Congenital anomalies of the kidney and urinary tract (CAKUT) have been reported in MWS patients. However, the role of ZEB2 in urinary tract development and the cellular and molecular mechanism underlining the CAKUT phenotypes in MWS remains unknown.
View Article and Find Full Text PDFKidney stone characteristics in diabetics versus nondiabetics at a tertiary care center in Saudi Arabia.
Urol Ann
January 2025
College of Medicine, King Saud Bin Abdelaziz University for Health Sciences, Jeddah, Saudi Arabia.
Background: Kidney stones can significantly impact individuals, but existing literature often overlooks the comprehensive effects by not considering the various factors such as stone size, presence of obstruction, and treatment methods, among those with and without diabetes. This study seeks to explore the relationship between diabetes and kidney stone formation, addressing these gaps in research.
Methodology: This cross-sectional study assesses the diverse impacts of kidney stones on adults diagnosed with type 2 diabetes mellitus and nondiabetic adults from 2019 to 2022 in Jeddah, Saudi Arabia.
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