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Monkeypox in Bulgaria: Significance of Various Clinical Samples, Clinical Manifestation, and Molecular Detection.
J Clin Med
August 2024
National Reference Laboratory "Measles, Mumps, Rubella", Department of Virology, National Center of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria.
Article Synopsis
- Monkeypox (mpox) is currently the leading zoonotic disease caused by the orthopoxvirus, with unusual transmission patterns recently observed outside of endemic regions.
- A study was conducted on 181 clinical samples from 42 Bulgarian patients to investigate the presence of monkeypox virus (MPXV) and other orthopoxvirus (OPXV) DNA.
- The results showed MPXV DNA in 23 samples and OPXV DNA in 20 samples, with the highest detection rates in vesicular contents and respiratory secretions, indicating that the virus can persist in various bodily fluids for more than two weeks post-infection.
A Rare Case of Subacute Sclerosing Panencephalitis in an Immunized Patient.
Cureus
June 2024
Pediatrics, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
This study presents a case of subacute sclerosing panencephalitis (SSPE), a rare neurologic disorder characterized by brain inflammation, typically triggered by measles virus reactivation or an abnormal immune response to it. This case involves a five-year-old male child with persistent fever, declining motor function, excessive sleepiness, and myoclonic jerks. MRI indicated potential ischemic changes or encephalitis, while electroencephalography showed SSPE-consistent patterns.
View Article and Find Full Text PDFStatus Dystonicus: An Atypical Presentation of Subacute Sclerosing Panencephalitis.
Indian J Pediatr
April 2024
Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, 249203, Uttarakhand, India.
Subacute Sclerosing Panencephalitis in a 63-Year-Old Woman Presenting as Generalized Choreoathetosis.
Neurohospitalist
October 2023
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
The persistence of measles virus infection in childhood and early adolescence can rarely lead to a fatal progressive neurodegenerative disorder known as subacute sclerosing panencephalitis (SSPE), characterized by behavioral disturbances and intellectual disability followed by myoclonic jerks and occasional negative myoclonus. Movement disorders are rarely presenting manifestations in SSPE. We herein report a 63-year-old woman with generalized choreoathetosis as the presenting manifestation of stage-I SSPE.
View Article and Find Full Text PDFMonkeypox detection using deep neural networks.
BMC Infect Dis
June 2023
Center for Health Informatics and Technology, The Maersk Mc-Kinney Moller Institute, University of Southern Denmark, Odense, Denmark.
Background: In May 2022, the World Health Organization (WHO) European Region announced an atypical Monkeypox epidemic in response to reports of numerous cases in some member countries unrelated to those where the illness is endemic. This issue has raised concerns about the widespread nature of this disease around the world. The experience with Coronavirus Disease 2019 (COVID-19) has increased awareness about pandemics among researchers and health authorities.
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