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Efficacy of Propranolol and Pingyangmycin combination therapy in infantile hemangiomas: Correlation with VEGF levels.
J Stomatol Oral Maxillofac Surg
November 2024
Oral and Maxillofacial Surgery Department, Wuxi Stomatological Hospital 214000, Wuxi, PR China. Electronic address:
Article Synopsis
- The study focuses on evaluating the effectiveness of a treatment combining propranolol and pingyangmycin for infantile hemangiomas (IH), which are common vascular tumors in infants that can grow rapidly.
- Over 12 months, 120 children participated, with results showing significant reductions in both the Hemangioma Activity Score and serum levels of vascular endothelial growth factor (VEGF), indicating improved condition with treatment.
- The treatment was mostly well-tolerated, with mild and temporary side effects reported in 15% of patients, and there was a strong negative correlation between VEGF levels and hemangioma activity, suggesting the therapy's effectiveness relates to lowering VEGF.
Propranolol As a Treatment Option for Chylous Effusions and Chylous Ascites in Fetuses and Neonates: A Systematic Review.
J Pediatr Pharmacol Ther
October 2024
Masters of Science in Physician Assistant Studies (BC, GZ, SPNO, ECN, SJR), Sacred Heart University, Fairfield, CT.
Objective: Chylous effusion and chylous ascites are rare but serious conditions that affect both fetuses and neonates. Previous studies have documented chylous effusions or chylous ascites treatment with medications as an adjunct to respiratory support and dietary modifications, but no formal recommendations have been made. New literature suggests propranolol as an effective and safe treatment option, though no randomized clinical studies have been published to date.
View Article and Find Full Text PDFSafety of Prior Propranolol Therapy for Infantile Hemangioma.
Pediatr Dermatol
November 2024
Department of Dermatology, West Virginia University, Morgantown, West Virginia, USA.
Article Synopsis
- * A study using the TrinetX database looked at children aged 10-17 who received propranolol for IH and assessed risks of growth impairment, sleep disorders, learning disabilities, and diabetes mellitus.
- * The results indicated no significant long-term risks for these adverse effects in children treated with propranolol for IH during infancy, supporting the medication's safety.
Efficacy and safety of atenolol versus propranolol for treatment of infantile haemangioma: A narrative review.
Clin Exp Dermatol
October 2024
Department of Paediatric Dermatology, Sydney Children's Hospital Randwick.
Article Synopsis
- Infantile haemangiomas (IH) are the most common benign vascular tumors in children and often require treatment for cases that cause disfigurement or functional impairment.
- Propranolol has been the first-line treatment since 2008, but it can lead to side effects like hypoglycemia and sleep disturbances.
- Atenolol, a different beta blocker, has shown similar effectiveness with fewer adverse effects, suggesting it might be a better alternative, although more research is needed on dosing and managing rebound growth.
Oral propranolol for the treatment of hemangiomas in high-risk infants: safety and cost analysis of outpatient-initiated therapy.
Front Med (Lausanne)
September 2024
Department of Dermatology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Article Synopsis
- - The study aimed to evaluate the safety and cost-effectiveness of oral propranolol for treating high-risk infantile hemangiomas in outpatient settings compared to inpatient care.
- - Results showed that the majority of patients had improved heart metrics without serious side effects, and follow-up tests on day ten displayed normal physiological functions.
- - Treatment costs were significantly lower in outpatient settings, suggesting that this approach is safe and economically beneficial, making it a valuable option for hospitals lacking dermatology departments.
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