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Gliclazide protects ionizing radiation-induced intestinal injury in mice by inhibiting oxidative stress and caspase-3.
BioTechnologia (Pozn)
December 2024
Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Gliclazide (GLZ), an oral antihyperglycemic medication, has additional beneficial effects, such as anti-inflammatory and antioxidant properties, besides lowering blood glucose levels. In this study, the radio-protective effect of GLZ was evaluated against ionizing radiation (IR)-induced intestinal injury in mice. Eight groups of mice were randomized as follows: control, GLZ (5, 10, and 25 mg/kg), IR (6 Gy), and IR + GLZ (at 5, 10, and 25 mg/kg).
View Article and Find Full Text PDFImpact of Co-doping Eu and Gd in HMO-Based Glasses for Structural and Optical Properties and Radiation Shielding Enhancement.
Luminescence
January 2025
Department of Physics, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.
Eu-Gd co-doped glasses composed of 15BO-12SiO-(40-x)TeO-3EuO-xGdO-12BiO-8BaO-10ZnO with x = 0-4 mol% (coded as EuGd-x) were fabricated using melt quench approach to develop transparent radiation shielding system. Their structural, optical and mechanical properties were examined. 5.
View Article and Find Full Text PDFPb-free metal oxide-based epoxy resin nanocomposites for radiation protection: Physical evaluation analysis approach.
Heliyon
January 2025
Department of Physics, College of Science, De La Salle University, Philippines.
Exposure to mid-energy radiation poses significant health risks, necessitating the development of effective shielding materials. Traditional lead-based shields, while effective, have significant drawbacks including toxicity and environmental concerns. This study investigates the potential of lead-free epoxy resin nanocomposites, incorporating bismuth oxide, nickel oxide, and cerium oxide, for mid-energy radiation protection.
View Article and Find Full Text PDFBioactive Silk Cryogel Dressing with Multiple Physical Cues to Control Cell Migration and Wound Regeneration.
Adv Healthc Mater
January 2025
State Key Laboratory of Radiation Medicine and Radiation Protection, Institutes for Translational Medicine, Soochow University, Suzhou, Jiangsu Province, 215123, P. R. China.
Introducing multiple physical cues to control cell behaviors effectively is considered as a promising strategy in developing bioactive wound dressings. Silk nanofiber-based cryogels are developed to favor angiogenesis and tissue regeneration through tuning hydrated state, microporous structure, and mechanical property, but remained a challenge to endow with more physical cues. Here, β-sheet rich silk nanofibers are used to develop cryogels with nanopore structure.
View Article and Find Full Text PDFBehavioral assessment to evaluate the analgesic and anti-inflammatory effects of Fagonia bruguieri var. laxa boiss by targeting pro-inflammatory cytokines and prostaglandin pathways.
J Ethnopharmacol
January 2025
College of Pharmacy, Shenzhen Technology University, Shenzhen, 518118, Guangdong, China; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, 90112, Songkhla, Thailand; Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, 90112, Songkhla, Thailand. Electronic address:
Ethnopharmacological Relevance: Fagonia bruguieri var. laxa Boiss., also known as Dhamansa or Dhamaran, is a well-known xerophyte traditionally used for managing pain, inflammation, fever, and related disease conditions.
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