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Dose- and application route-dependent effects of betahistine on behavioral recovery and neuroplasticity after acute unilateral labyrinthectomy in rats.
Front Neurol
July 2023
German Center for Vertigo and Balance Disorders, DSGZ, LMU University Hospital, LMU Munich, Munich, Germany.
Article Synopsis
- Betahistine is often used for vestibular disorders, but its oral form may not be effective due to first-pass metabolism, prompting a study on alternative administration routes and doses for better outcomes.
- Sixty rats underwent unilateral labyrinthectomy and were treated with different forms of betahistine, tested for behavioral recovery and changes in brain activity over 30 days.
- Results showed that certain treatments, particularly high-dose intravenous and subcutaneous betahistine, significantly improved movement and postural control compared to sham treatment, indicating that application route and concurrent medication impact effectiveness.
Dynamic whole-brain metabolic connectivity during vestibular compensation in the rat.
Neuroimage
February 2021
German Center for Vertigo and Balance Disorders, University Hospital of Munich, LMU Munich, Munich, Germany; Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Unilateral damage to the inner ear results in an acute vestibular syndrome, which is compensated within days to weeks due to adaptive cerebral plasticity. This process, called central vestibular compensation (VC), involves a wide range of functional and structural mechanisms at the cellular and network level. The short-term dynamics of whole-brain functional network recruitment and recalibration during VC has not been depicted in vivo.
View Article and Find Full Text PDFKinetics, intermediates and acute toxicity of arsanilic acid photolysis.
Chemosphere
July 2014
Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:
Arsanilic acid (4-amino phenyl arsenic acid, ASA) is widely used in poultry production as feed additives, while most of ASA in the feed is excreted in the animal manure and released into the environment. However, the environmental behaviors of ASA were not well understood. In the present study, the photolysis behaviors of ASA and the toxicity of its metabolites to luminescent bacterium were studied.
View Article and Find Full Text PDFArsanilic acid causes apoptosis and oxidative stress in rat kidney epithelial cells (NRK-52e cells) by the activation of the caspase-9 and -3 signaling pathway.
Drug Chem Toxicol
January 2014
College of Veterinary Medicine, Hunan Agricultural University, 19 East Lake Road, Changsha, Hunan 410128 , China and.
Arsenic exists widely in rock, water and air, and arsanilic acid (also known as aminophenyl arsenic acid) is an organoarsenic compound and has been used as feed additives. Organoarsenic compounds in foodstuff cause adverse effects, including acute and chronic toxicity, in animals and humans. However, little is known about the cellular toxicity and mechanisms of organic arsenic on the kidney.
View Article and Find Full Text PDFSynthesis of a fluorescently labeled compound for the detection of arsenic-induced apoptotic HL60 cells.
Med Chem
March 2012
Laboratorio de Biomembranas, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal, B1876BXD, Buenos Aires, Argentina.
Arsenic compounds have shown medical usefulness since they proved to be effective in causing complete remission of acute promyelocytic leukemia. In this work we obtained a fluorescently labeled arsenic compound that can be used with current fluorescence techniques for basic and applied research, focused on arsenic-induced apoptosis studies. This compound is an arsanilic acid bearing a covalently linked FITC that was chemically synthesized and characterized by fluorescence, UV-Vis, mass and FTIR spectrometry.
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