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Pump-Free Microfluidics for Cell Concentration Analysis on Smartphones in Clinical Settings (SmartFlow): Design, Development, and Evaluation.
JMIR Biomed Eng
December 2024
School of Interactive Computing, Georgia Institute of Technology, Atlanta, GA, United States.
Background: Cell concentration in body fluid is an important factor for clinical diagnosis. The traditional method involves clinicians manually counting cells under microscopes, which is labor-intensive. Automated cell concentration estimation can be achieved using flow cytometers; however, their high cost limits accessibility.
View Article and Find Full Text PDFLiving Apart Together and Older Adults' Mental Health in the United Kingdom.
J Gerontol B Psychol Sci Soc Sci
December 2024
Department of Geography, University College London, London, UK.
Objectives: Living apart together (LAT)-intimate partners living in separate households-is a common partnership type among older adults. Although the mental health benefits of intimate partnerships are widely documented, how LAT relates to older adults' mental health remains understudied.
Methods: Analyzing Waves 3-13 (2011-2023) of the United Kingdom Household Longitudinal Study, we use fixed effects models to examine (1) how older adults' mental health varies with LAT, marriage, cohabitation, and singlehood (never married, widowed, divorced/separated); and (2) how transitions into and out of LAT, compared to marriage and cohabitation, relate to older adults' mental health.
Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice.
Exp Biol Med (Maywood)
December 2024
Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Cognitive deficit is a debilitating complication of sickle cell disease (SCD), with a multifactorial etiopathogenesis. Here we show that neuroinflammation and dysregulation in lipidomics and transcriptomics profiles are major underlying mechanisms of social stress-induced cognitive deficit in SCD. Male Townes sickle cell (SS) mice and controls (AA) were exposed to social stress using the repeat social defeat (RSD) paradigm concurrently with or without treatment with minocycline.
View Article and Find Full Text PDFSmart filtering facepiece respirator with self-adaptive fit and wireless humidity monitoring.
Biomaterials
March 2025
Wearable Intelligent Systems and Healthcare Center (WISH Center), Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, 30332, USA; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University School of Medicine, Atlanta, GA, 30332, USA; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA. Electronic address:
The widespread emergence of airborne diseases has transformed our lifestyle, and respirators have become an essential part of daily life. Nevertheless, finding respirators that fit well can be challenging due to the variety of human facial sizes and shapes, potentially compromising protection. In addition, the current respirators do not inform the user of the air quality in case of continuous long-term use.
View Article and Find Full Text PDFDeep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis.
Sci Transl Med
September 2024
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30309, USA.
Schistosomiasis, a highly prevalent parasitic disease, affects more than 200 million people worldwide. Current diagnostics based on parasite egg detection in stool detect infection only at a late stage, and current antibody-based tests cannot distinguish past from current infection. Here, we developed and used a multiplexed antibody profiling platform to obtain a comprehensive repertoire of antihelminth humoral profiles including isotype, subclass, Fc receptor (FcR) binding, and glycosylation profiles of antigen-specific antibodies.
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