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Achieving the state of Georgia 25% HIV incidence reduction target among men who have sex with men in Atlanta through expanded use of multimodal pre-exposure prophylaxis: A mathematical model.
PLoS One
January 2025
Maple Health Group, LLC, New York, United States of America.
The US faces substantial demographic and geographic disparities in both HIV burden and access to pre-exposure prophylaxis (PrEP), an effective strategy to prevent HIV acquisition. Long-acting cabotegravir (CAB) is a novel, injectable PrEP option which demonstrated superior reduction in risk of HIV acquisition compared to daily-oral PrEP in the HPTN083 trial. We modelled the impact of increased PrEP initiations and the introduction of long-acting CAB on HIV incidence among men who have sex with men (MSM) in Atlanta, Georgia, a population with a high burden of HIV.
View Article and Find Full Text PDFAjwa date extract (): Phytochemical analysis, antiviral activity against herpes simplex virus-I and coxsackie B4 virus, and in silico study.
Saudi Med J
January 2025
From the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Objectives: To investigate the phytochemical composition of Ajwa date extract and evaluate its antiviral activity and mechanism of action.
Methods: High perfomance liquid chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry were used to analyze the phytochemical profile of Ajwa date extract. The antiviral activity was assessed using the MTT colorimetric assay against herpes simplex virus type I (HSV-I) and coxsackievirus B4 (CVB-4).
Chemical characterization and evaluation of antiviral activity of two fucoidans extracted from Mediterranean brown seaweeds, Padina pavonica and Dictyopteris membranacea.
Lett Appl Microbiol
January 2025
Laboratory for Chemical, Galenic and Pharmacological Development of Drugs (LR12ES09), Faculty of Pharmacy of Monastir, University of Monastir, Tunisia.
Brown seaweeds are known for their bioactive compounds, particularly sulfated polysaccharides such as fucoidans, which have demonstrated antiviral properties. However, limited studies have focused on the antiviral potential of fucoidans extracted from Mediterranean brown seaweeds. In this study, two brown seaweeds Padina pavonica and Dictyopteris membranacea (Fuc-Pad and Fuc-Dic) were collected from monastir coasts, Tunisia, and a specific extraction protocol was employed to obtain fucoidans.
View Article and Find Full Text PDFThe Compound AT13148 Targeting AKT Suppresses Dengue Virus 2 Replication.
Vector Borne Zoonotic Dis
January 2025
Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi'an, China.
Dengue virus (DENV) infection, caused by serotypes DENV 1-4, represents a significant global public health challenge, with no antiviral drugs currently available for treatment. The host Protein kinase B (AKT) signaling pathway is crucial for DENV infection, presenting a potential target for antiviral drug development. This study aimed to evaluate the antiviral activity of kinase inhibitors that target the AKT pathway, focusing on the compound AT13148.
View Article and Find Full Text PDF[Activity of flavonoids of natural origin on SARS-CoV-2 infections].
Postepy Biochem
December 2024
Katedra Biotechnologii, Wydział Nauk Biologicznych, Uniwersytet Zielonogórski.
Coronaviruses cause diseases of the respiratory tract, gastrointestinal tract and central nervous system, which threaten human health and contribute to economic losses. Innovative production technologies make it possible to use bioactive compounds as antiviral agents. Most fruits, vegetables and plant products contain flavonoids.
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