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Deep brain stimulation for Tourette's syndrome.
Neurosurg Rev
October 2024
Department of Neurosurgery, New York University Grossman School of Medicine, New York City, NYC, USA.
Article Synopsis
- Tourette's syndrome is a neuropsychiatric disorder marked by severe motor and vocal tics, often accompanied by other mental health issues, and can require more invasive treatments like Deep Brain Stimulation (DBS) for severe cases that don't respond to standard therapies.
- DBS targets specific brain regions, such as the globus pallidus internus and the thalamus, and has shown effectiveness in reducing tic severity and improving patients' quality of life, though results can vary based on factors like electrode placement.
- Ethical concerns surrounding DBS include surgical risks, the importance of informed consent, and potential impacts on cognitive and emotional development, highlighting the need for ongoing research and ethical discussions as DBS technology evolves.
CM-Pf deep brain stimulation in polyneuromodulation for epilepsy.
Epileptic Disord
October 2024
Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA.
Article Synopsis
- Neuromodulation is a promising option for drug-resistant epilepsy, showcasing case studies involving patients with multiple deep brain stimulators and their responses.
- A thorough review of literature indicates that combining vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation is increasingly reported for treating these patients.
- A notable case is presented where a 28-year-old male with drug-resistant focal epilepsy achieved a 75% seizure reduction through the centromedian-parafascicular deep brain stimulation after inadequate results from previous treatments, emphasizing the safety and effectiveness of dual-device therapies.
Concerns about efficacy of deep brain stimulation (DBS) in centromedian-parafascicular thalamic complex for rapid onset dystonia-parkinsonism (DYT12-ATP1A3).
Brain Stimul
April 2024
Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Somatosensory evoked potentials recorded from DBS electrodes: the origin of subcortical N18.
J Neural Transm (Vienna)
April 2024
Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
The different peaks of somatosensory-evoked potentials (SEP) originate from a variety of anatomical sites in the central nervous system. The origin of the median nerve subcortical N18 SEP has been studied under various conditions, but the exact site of its generation is still unclear. While it has been claimed to be located in the thalamic region, other studies indicated its possible origin below the pontomedullary junction.
View Article and Find Full Text PDFMicropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs.
Front Neuroanat
January 2024
Department of Anatomy and Neuroscience, Autónoma de Madrid University, Madrid, Spain.
Introduction: In primates, including humans, the centromedian/parafascicular (CM-Pf) complex is a key thalamic node of the basal ganglia system. Deep brain stimulation in CM-Pf has been applied for the treatment of motor disorders such as Parkinson's disease or Tourette syndrome. Rodents have become widely used models for the study of the cellular and genetic mechanisms of these and other motor disorders.
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