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Introduction: Free radical-mediated oxidative renal tubular injury secondary to hyperoxaluria is a proposed mechanism in the formation of calcium oxalate stones. Vitamin E, an important physiologic antioxidant, has been shown in rat models to prevent calcium oxalate crystal deposition. Our objective was to determine if low dietary vitamin E intake was associated with a higher incidence of stones.
View Article and Find Full Text PDFPatients with end-stage renal disease (ESRD) undergoing chronic hemodialysis are at an increased risk of developing spondylodiscitis, an infectious condition affecting the vertebral column. In this case report, we present a 22-year-old male with ESRD, a history of hyperoxaluria, nephrolithiasis, and anemia, who developed spondylodiscitis. Notably, pathological examination of tissue samples obtained during surgical intervention revealed the presence of polarized calcium oxalate crystals within the lumbar laminae and spinal discs, a rare finding in this clinical context.
View Article and Find Full Text PDFOxalate nephropathy associated with glyoxylate-containing hair-straightening products: a call for caution.
Kidney Int
December 2024
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Recent reports have described acute kidney injury in otherwise healthy individuals after exposure to hair-straightening products. In this issue, Robert et al. help elucidate the underlying mechanisms in a murine model that replicates the human pathology.
View Article and Find Full Text PDFThe Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation.
Biology (Basel)
October 2024
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Article Synopsis
- The study investigates how oxalate affects rat renal tubular epithelial cells using a proteomic approach to identify changes in protein expression.
- It found 268 different proteins that were expressed differently in cells treated with oxalate compared to control cells, highlighting pathways like oxidative stress and inflammation.
- Certain proteins were identified as potential biomarkers and therapeutic targets, providing insights into preventing kidney damage and kidney stone formation caused by high oxalate levels.
Immune-inflammatory process in nephrolithiasis: A bibliometric analysis (2000-2023).
Heliyon
August 2024
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Article Synopsis
- Research on nephrolithiasis, or kidney stone formation, is crucial due to its high incidence and economic impact, with a focus on the immune-inflammatory processes involved in its development.
- A total of 370 articles on this topic published since 2000 were analyzed using tools like VOSviewer and CiteSpace, revealing significant growth in research over the past five years, particularly from China and the USA.
- Key findings highlighted important research themes such as inflammation and oxidative stress, with the most prolific author being Khan SR, whose work is highly cited, providing insights into current trends and future directions in this field.
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