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Solid organ transplantation and gut microbiota: a review of the potential immunomodulatory properties of short-chain fatty acids in graft maintenance.

Front Cell Infect Microbiol

March 2024

National Institute of Health and Medical Research (FRANCE) (INSERM), Univ. Limoges, Pharmacology & Transplantation, U1248, Limoges, France.

Transplantation is the treatment of choice for several end-stage organ defects: it considerably improves patient survival and quality of life. However, post-transplant recipients may experience episodes of rejection that can favor or ultimately lead to graft loss. Graft maintenance requires a complex and life-long immunosuppressive treatment.

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Background: Laparoscopic 1- (single-) anastomosis gastric bypass (OAGB) was developed as a simplified technique of Roux-en-Y gastric bypass (RYGB), but super long-term data are lacking.

Objectives: To evaluate the risks and long-term results of OAGB over a period of 20 years.

Setting: Tertiary teaching hospital.

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Malignancies following lung transplantation.

Transplant Proc

October 2007

Department of Thoracic Surgery, University of Rome La Sapienza, Rome, Italy.

During the last 2 decades, long-term survival after lung transplantation has significantly improved. However, among the complications related to the continuous administration of immunosuppressive drugs, malignancy plays an important role. We retrospectively revisited our series of patients to report our experience.

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Aim: Mizoribine (MZR) is a purine antimetabolic immunosuppressant agent that has few little severe adverse events. We studied whether maintenance therapy with MZR and prednisolone (PSL) in severe proliferative lupus nephritis patients could improve immunity, reduce proteinuria, prevent renal relapse, and reduce steroid dose.

Method: Long-term maintenance therapy with MZR and PSL was evaluated in ten patients with biopsy-proven proliferative lupus nephritis.

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The aim of this paper is to present our own experience in the treatment of cystic blebs in children and young adults. This complication, which is the most popular after trabeculectomy with antimetabolic agents, can be the reason of late endophthalmitis. Surgical treatment is one of the method to prevent it.

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