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[F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT receptors.

Eur J Med Chem

January 2025

Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Wilhelm-Johnen-Straße, 52428, Jülich, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, Kerpener Straße 62, 50937, Cologne, Germany.

Serotonergic 5-HT receptors in the cortex and other forebrain structures have been linked to cognitive, emotional and memory processes. In addition, dysfunction or altered expression of these receptors is associated with neuropsychiatric and neurodegenerative disorders. [F]R91150 is a candidate radiotracer for positron emission tomography (PET) imaging of 5-HT receptors, which showed promising properties in in vitro studies.

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This paper presents the results of microbial corrosion tests on M0-grade copper under conditions simulating a geological repository for radioactive waste at the Yeniseisky site (Krasnoyarsk Krai, Russia). The work used a microbial community sampled from a depth of 450 m and stimulated with glucose, hydrogen and sulfate under anaerobic conditions. It was shown that the maximum corrosion rate, reaching 9.

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Uptake of metals, metalloids, and radiocesium varies with habitat use among passerine communities at coal combustion and nuclear fission legacy waste sites.

Environ Pollut

December 2024

Savannah River Ecology Laboratory, University of Georgia, P.O. Drawer E, Aiken, SC, 29802, USA; Warnell School of Forestry and Natural Resources, University of Georgia, 180 E Green St, Athens, GA, 30602, USA.

Releases of coal combustion and nuclear fission wastes create contaminated landscapes that pose long-term management challenges. Efforts to facilitate the natural attenuation of legacy wastes in the environment can provide attractive habitat for passerine birds. Passerines have diverse foraging and nesting behaviors that lead to heterogenous contaminant exposure, yet few studies investigate contaminant uptake in passerines on a community scale.

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Preparation of Protein Lysates Using Biorthogonal Chemical Reporters for Click Reaction and in-Gel Fluorescence Analysis.

Bio Protoc

November 2024

State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.

Bioorthogonal chemical reporters are non-native chemical handles introduced into biomolecules of living systems, typically through metabolic or protein engineering. These functionalities can undergo bioorthogonal reactions, such as copper-catalyzed alkyne-azide cycloaddition (CuAAC), with small-molecule probes, enabling the tagging and visualization of biomolecules. This approach has greatly enhanced our understanding of cellular dynamics, enzyme targeting, and protein post-translational modifications.

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Inkjet-based facile fabrication of a copper ferrocyanide-embedded magnetic alginate microadsorbent for highly enhanced cesium removal.

Carbohydr Polym

January 2025

Decommissioning Technology Research Division, Korea Atomic Energy Research Institute, 989-111 Daedukdaero, Yuseong, Daejeon 34057, Republic of Korea.

For the first time, simple and facile fabrication of a magnetic alginate microadsorbent via piezoelectric inkjet technology was developed for the selective removal of Cs via magnetic separation. Through the ejection of an alginate solution containing potassium ferrocyanide and magnetic nanoparticles (MNPs) into a Cu solution via an inkjet device, the fabrication of a copper ferrocyanide-embedded magnetic alginate microadsorbent (CuFC-MAM) with an average size of 39.38 μm was easily achieved in a one-pot fabrication process; here, the Cu ions acted as both a cross-linker for the gelation of alginate and a Cu source for the in situ synthesis of CuFC with potassium ferrocyanide.

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