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Basic principles of therapeutic plasma exchange.
Transfus Apher Sci
April 2023
Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address:
Therapeutic plasma exchange is a method of treatment for clinical conditions that represent diverse fields of medicine. The rationale for this mode of therapy is based on sound mathematical modeling of the synthesis and removal of large molecules, usually proteins, from the circulation. The basic assumptions underlying therapeutic plasma exchange are that a clinical illness is caused by, or related to, a pathogenic substance in the plasma, and that removing that substance from the plasma will alleviate the patient's illness.
View Article and Find Full Text PDFFamilial Hypocalciuric Hypercalcemia Type 1 and Autosomal-Dominant Hypocalcemia Type 1: Prevalence in a Large Healthcare Population.
Am J Hum Genet
June 2020
Regeneron Genetics Center, Tarrytown, NY 10591, USA.
The calcium-sensing receptor (CaSR) regulates serum calcium concentrations. CASR loss- or gain-of-function mutations cause familial hypocalciuric hypercalcemia type 1 (FHH1) or autosomal-dominant hypocalcemia type 1 (ADH1), respectively, but the population prevalence of FHH1 or ADH1 is unknown. Rare CASR variants were identified in whole-exome sequences from 51,289 de-identified individuals in the DiscovEHR cohort derived from a single US healthcare system.
View Article and Find Full Text PDFDual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism.
ACS Pharmacol Transl Sci
November 2018
Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Monash University, Parkville, Victoria 3052, Australia.
Negative allosteric modulators (NAMs) of the human calcium-sensing receptor (CaSR) have previously failed to show efficacy in human osteoporosis clinical trials, but there is now significant interest in repurposing these drugs for hypocalcemic disorders and inflammatory lung diseases. However, little is known about how CaSR NAMs inhibit the response to endogenous activators. An improved understanding of CaSR negative allosteric modulation may afford the opportunity to develop therapeutically superior CaSR-targeting drugs.
View Article and Find Full Text PDFThe effect of metritis and subclinical hypocalcemia on uterine involution in dairy cows evaluated by sonomicrometry.
J Reprod Dev
October 2016
Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, 30173 Hannover, Germany.
The objective of this study was to examine the effects of metritis and subclinical hypocalcemia on reduction of uterine size in dairy cows using ultrasonography and sonomicrometry. Four piezoelectric crystals were implanted via laparotomy into the myometrium of the pregnant uterine horn of 12 pluriparous Holstein Friesian cows 3 weeks before the calculated calving date. Sonometric measurements were conducted daily from 2 days before parturition (= Day 0) until Day 14 after calving and then every other day until Day 28.
View Article and Find Full Text PDFInherited disorders of calcium and phosphate metabolism.
Curr Opin Pediatr
April 2014
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Purpose Of Review: Inherited disorders of calcium and phosphate homeostasis have variable presentation and can cause significant morbidity. An understanding of the mode of inheritance and pathophysiology of these conditions will help in the diagnosis and early institution of therapy.
Recent Findings: Identification of genetic mutations in humans and animal models has advanced our understanding of many inherited disorders of calcium and phosphate regulation.
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