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Changes in systemic haemodynamics, regional myocardial function and perfusion induced by alinidine in pigs with and without narrowed coronary arteries.
Eur Heart J
December 1987
Laboratory for Experimental Cardiology, Thoraxcenter, Rotterdam, The Netherlands.
Intravenous administration of 0.2-6.0 mg kg-1 of alinidine, an N-allyl derivative of clonidine, exerted a pronounced bradycardic action and also decreased the maximum rate of rise in left ventricular pressure (max LVdP/dt), cardiac output, and mean arterial blood pressure in anaesthetized as well as in conscious pigs.
View Article and Find Full Text PDFFurther studies of alinidine induced bradycardia in the presence of caesium.
Cardiovasc Res
May 1986
Alinidine, the N-allyl derivative of clonidine, reduces heart rate in animals and man by a selective action on the sinoatrial node. In this study, in the presence of caesium, which blocks the time dependent inward current activated by hyperpolarisation (ih or if), alinidine still caused a concentration related bradycardia in the rabbit sinoatrial node. Within the clinical range of concentrations of alinidine the curve relating heart rate to alinidine concentration in the presence of caesium was parallel to that observed in its absence.
View Article and Find Full Text PDFAlinidine (ST 567), an N-allyl derivative of clonidine, slowed the heart rate of conscious rabbits by 41 +/- 2.3 (S.E.
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