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Mixed Adenosquamous Cell Carcinoma of the Prostate with Paired Sequencing on the Primary and Liver Metastasis.
Curr Oncol
April 2024
Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR 97239, USA.
This report aims to shed light on the intricate challenges encountered during the diagnosis and treatment of an uncommon variant of prostate cancer-mixed adenosquamous cell carcinoma of the prostate. Prostate cancers of this nature pose distinctive diagnostic and therapeutic dilemmas due to their rarity and complex histological composition. We present a case of a 63-year-old man with metastatic prostate cancer, featuring adenocarcinoma with squamous cell differentiation, who underwent a multimodal treatment approach.
View Article and Find Full Text PDFGroup B Streptococcus Persistently Colonizing the Adenosquamous Carcinoma of the Lung: A Blessing in Disguise?
Cureus
April 2024
Interventional Pulmonology, Capital Health Regional Medical Center, Trenton, USA.
(GBS), also known as , is a gram-negative, beta-hemolytic facultative anaerobe that causes neonatal pneumonia and sepsis. The neoplastic epithelial cells in adults, especially those of squamous origin, can show special adhesive properties toward GBS, which tends to reside within these tumors. There are some animal and human studies proving this association.
View Article and Find Full Text PDFGATA3 Expression in Prostatic Adenosquamous Carcinoma: A Potential Diagnostic Pitfall.
Int J Surg Pathol
February 2025
Department of Pathology, Stanford Medical Center, Stanford, CA, USA.
Urothelial carcinoma and prostatic adenocarcinoma can have overlapping histologic features and in some instances pose challenges to pathologists. GATA binding protein 3 (GATA3) immunohistochemistry (IHC) is a well-established tool to aid in this specific diagnostic dilemma as it has been shown to be a sensitive marker for urothelial carcinoma and a putatively specific marker in excluding prostatic adenocarcinoma. However, in encountering an index tumor of prostatic adenosquamous carcinoma positive for GATA3, herein we sought to investigate this potential diagnostic pitfall in a larger series of tumors.
View Article and Find Full Text PDFGene Expression Analysis for Uterine Cervix and Corpus Cancer Characterization.
Genes (Basel)
February 2024
Department of Computer Engineering, Automatics and Robotics, C.I.T.I.C., University of Granada, Periodista Rafael Gómez Montero, 2, 18014 Granada, Spain.
Article Synopsis
- * A three-gene signature was found to classify different types of uterine cancer with 100% accuracy, while a two-gene miRNA signature showed strong potential in regulating these genes with an 82% performance score.
- * The research also identified a unique gene signature for cervical adenocarcinoma and suggested that mixed cervical cancer samples may need to be re-evaluated based on expression patterns, enhancing insights into cancer diagnosis and treatment.
Primary Adenosquamous Carcinoma of the Prostate.
Diagnostics (Basel)
March 2024
Department of Pathology and Laboratory Medicine, University of California, Irvine, CA 92868, USA.
Prostate cancer accounts for 29% of malignant diagnoses among men in the United States and is the second leading cause of death from cancer. Effective screening methods and improved treatment have decreased the mortality rate significantly. This decreased mortality rate, however, does not apply to all histologic variants.
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